Modomics - A Database of RNA Modifications

ID Card:

Full name: Threonylcarbamoyladenosine tRNA methylthiotransferase MtaB
Synonym: YqeV
GI: 1730990
Orf: BSU25430
COG: COG0621
UniProt: P54462
Alpha Fold Predicted Structure: AF-P54462-F1
Enzyme type: methyltiotransferase
Position of modification - modification: t:37 - ms2t6A



Protein sequence:

MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVINTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDREKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFCIIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSELDTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYTMEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSKRTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEEENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLSS

Comments:

ms2 on t6A has been identified so far only in bacterial U36A37-containing tRNALys (anticodon U*UU, U* stands for a modified U-residue). The B. subtilis TmtB (Yqev) is a radical-SAM methyltransferase that displays two [4Fe-4S] clusters and one TRAM-domain. However, this characteristic tRNA binding motif is not involved in the discrimination of t6A37 or i6A37. A distinct methylthiotransferase (MiaB) is acting on i6A-containing tRNA, and another one (RimO) is acting exclusively on ribosomal protein S12.





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M A T V A F H T L G C K V N H Y E T E A I W Q L F K E A G Y E R R D F E Q T A D V Y V I N T C T V T N T G D K K S R Q V I R R A I R Q N P D G V I C V T G C Y A Q T S P A E I M A I P G V D I V V G T Q D R E K M L G Y I D Q Y R E E R Q P I N G V S N I M K A R V Y E E L D V P A F T D R T R A S L K I Q E G C N N F C T F C I I P W A R G L L R S R D P E E V I K Q A Q Q L V D A G Y K E I V L T G I H T G G Y G E D M K D Y N F A K L L S E L D T R V E G V K R I R I S S I E A S Q I T D E V I E V L D R S D K I V N H L H I P I Q S G S N T V L K R M R R K Y T M E F F A D R L N K L K K A L P G L A V T S D V I V G F P G E T E E E F M E T Y N F I K E H K F S E L H V F P Y S K R T G T P A A R M E D Q V D E N V K N E R V H R L I A L S D Q L A K E Y A S Q Y E N E V L E I I P E E A F K E T E E E N M F V G Y T D N Y M K V V F K G T E D M I G K I V K V K I L K A G Y P Y N E G Q F V R V V E D E I T E H M R L S S
50100150200250300350400450SequenceGHTBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-P54462-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-P54462-F1.cif  
DSSP Secondary Structures   P54462.dssp  





Publications:

Links:

_PubMed_