Modomics - A Database of RNA Modifications

ID Card:

Full name: Threonylcarbamoyladenosine tRNA methylthiotransferase
Synonym: tRNA-t(6)A37 methylthiotransferase, Cdkal1
GI: 21617853
COG: COG0621
UniProt: Q91WE6
Alpha Fold Predicted Structure: AF-Q91WE6-F1
Enzyme type: methylthiotransferase
Position of modification - modification: t:37 - ms2t6A



Protein sequence:

MPSASCDVLLDDIEDIISQEDSKPQDRQFSRKHVFPKVRRRNTQKYLQEEPRPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKVVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGKRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVERAKQSFQEGVCEIWLTSEDTGAYGRDIGTDLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMDMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKAEQVPAHVKKQRTKDLSRVFHSYNPYDHKIGERQQVLVTEESFDSKFYVAHNRFYEQVLVPKNPAFMGKMVEVDIYESGKHFLKGQPVSETRVYTPSISKPLAKGEVSGLTKEFRNRLGNHPNGTSDTCPATQHGSAYSRMVLQMSQYDCALKVATGLALLALLLHFWPDSLLTM

Comments:

ms2t6A is found at position 37 of tRNA-Lys(UUU) only. Eukaryotic MtaB (Cdkal1) displays C-terminal TRAM domain and 2 [4Fe-4S] clusters), characteristic features of the methylthiotransferase family, a subclass of the large radical AdoMet enzyme superfamily, including B. subtilis MtaB (YqeV) and E. coli or B. subtilis MiaE.





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M P S A S C D V L L D D I E D I I S Q E D S K P Q D R Q F S R K H V F P K V R R R N T Q K Y L Q E E P R P P S D S T I P G I Q K I W I R T W G C S H N N S D G E Y M A G Q L A A Y G Y K I T E N A S D A D L W L L N S C T V K N P A E D H F R N S I K K A Q E E N K K V V L A G C V P Q A Q P R Q D Y L K G L S I I G V Q Q I D R V V E V V E E T I K G H S V R L L G Q K K D N G K R L G G A R L D L P K I R K N P L I E I I S I N T G C L N A C T Y C K T K H A R G N L A S Y P I D E L V E R A K Q S F Q E G V C E I W L T S E D T G A Y G R D I G T D L P T L L W K L V E V I P E G A M L R L G M T N P P Y I L E H L E E M A K I L N H P R V Y A F L H I P V Q S A S D S V L M D M K R E Y C V A D F K R V V D F L K E K V P G I T I A T D I I C G F P G E T D Q D F Q E T V K L V E E Y K F P S L F I N Q F Y P R P G T P A A K A E Q V P A H V K K Q R T K D L S R V F H S Y N P Y D H K I G E R Q Q V L V T E E S F D S K F Y V A H N R F Y E Q V L V P K N P A F M G K M V E V D I Y E S G K H F L K G Q P V S E T R V Y T P S I S K P L A K G E V S G L T K E F R N R L G N H P N G T S D T C P A T Q H G S A Y S R M V L Q M S Q Y D C A L K V A T G L A L L A L L L H F W P D S L L T M
50100150200250300350400450500550SequenceGHTBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q91WE6-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q91WE6-F1.cif  
DSSP Secondary Structures   Q91WE6.dssp  





Publications:

Links:

_PubMed_