Modomics - A Database of RNA Modifications

ID Card:

Full name: Ribosomal RNA small subunit methyltransferase A
GI: 42573814
Orf: AT5G66360
COG: COG0030
UniProt: Q9FK02
Alpha Fold Predicted Structure: AF-Q9FK02-F1
Enzyme type: methyltransferase
Position of modification - modification: s:1914(1518) - m6,6A
s:1915(1519) - m6,6A



Protein sequence:

MILRLKDQTLIKINSTRSYLSSLVFRRDSHSQARTKPDHDRRRRGYERDVRIEEKKEHDGLFLCKSKGQHLLTNTRILDSIVRSSDIRPTDTVLEIGPGTGNLTMKLLEAAQNVVAVELDKRMVEILRKRVSDHGFADKLTIIQKDVLKTDFPHFDLVVANIPYNISSPLVAKLVYGSNTFRSATLLLQKEFSRRLLANPGDSDFNRLAVNVKLVADVKFVMDVSKREFVPPPKVDSSVIRITPKEIIPDVNVQEWLAFTRTCFGKKNKTLGSMFRQKKKVMELQSLSAGRHGSNVEVMNQTGGDSDSDVEEDGKDDLLCLDTDASMFKERVIEILRTNGFEEKRPSKLSHRELLHLLSLFNQAGIFFHDITSLQMDLHE

Comments:

The nuclear genome of Arabidopsis thaliana encodes three dimethylase/mtTFB-like proteins, one of which is Dim1B. The gene product is imported into mitochondria and catalyzes the formation of two adjacent dimethylated residues (m6,6A, positions 1518 and 1519; E. coli numberings) in the loop of a conserved hairpin near the 3'-end of small subunit rRNA. AdoMet is the methyl group donor.





Alpha Fold Predicted Structure:




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Protein sequence:

M I L R L K D Q T L I K I N S T R S Y L S S L V F R R D S H S Q A R T K P D H D R R R R G Y E R D V R I E E K K E H D G L F L C K S K G Q H L L T N T R I L D S I V R S S D I R P T D T V L E I G P G T G N L T M K L L E A A Q N V V A V E L D K R M V E I L R K R V S D H G F A D K L T I I Q K D V L K T D F P H F D L V V A N I P Y N I S S P L V A K L V Y G S N T F R S A T L L L Q K E F S R R L L A N P G D S D F N R L A V N V K L V A D V K F V M D V S K R E F V P P P K V D S S V I R I T P K E I I P D V N V Q E W L A F T R T C F G K K N K T L G S M F R Q K K K V M E L Q S L S A G R H G S N V E V M N Q T G G D S D S D V E E D G K D D L L C L D T D A S M F K E R V I E I L R T N G F E E K R P S K L S H R E L L H L L S L F N Q A G I F F H D I T S L Q M D L H E
50100150200250300350SequenceGHTSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9FK02-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9FK02-F1.cif  
DSSP Secondary Structures   Q9FK02.dssp  





Publications:

Links:

_PubMed_