RsmA from Methanocaldococcus jannaschii - protein summary.
Ribosomal RNA small subunit methyltransferase A
KsgA, Dim1, MJ1029
Position of modification - modification:
Archaeal RsmA belongs to the bacterial KsgA/eukaryal Dim1 super family of methyltransferases. It dimethylates two very conserved adjacent adenosines (positions 1518 and 1519 in E.coli numbering) in the loop of a conserved hairpin near the 3'-end of small subunit rRNA. AdoMet is the methyl group donor. Identity of the target nucleotides was identified by using a heterologous rRNA substrate.
Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution.
O'Farrell HC, Pulicherla N, Desai PM, Rife JP
Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases.
Pulicherla N, Pogorzala LA, Xu Z, O Farrell HC, Musayev FN, Scarsdale JN, Sia EA, Culver GM, Rife JP
J Mol Biol
Binding of adenosine-based ligands to the MjDim1 rRNA methyltransferase: implications for reaction mechanism and drug design.
O'Farrell HC, Musayev FN, Scarsdale JN, Rife JP
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