ID Card:
Full name:
Threonylcarbamoyl-AMP synthase
Synonym:
YrdC, STK_15260
GI:
15921819
COG:
COG0009
UniProt:
Q970S6
Structures:
|
3AJE |
2EQA |
4E1B |
Alpha Fold Predicted Structure:
AF-Q970S6-F1
Complex:
EKC/KEOPS
Enzyme type:
threonylcarbamoyladenosine synthetase predicted
Position of modification - modification:
t :37 - t6A
PDB Structures:
3AJE
2EQA
4E1B
}
3AJE
Structure Description:
Title:
Crystal Structure of the hypothetical Sua5 protein from Sulfolobus tokodaii
Classification:
X-Ray Diffraction
1.80
0.233
0.208
0.208
Abstract of the PDB Structure's related Publication:
Download RCSB-PDB Structures:
Protein sequence:
MTQIIKIDPLNPEIDKIKIAADVIRNGGTVAFPTETVYGLGANAFDGNACLKIFQAKNRPVDNPLIVHIADFNQLFEVAKDIPDKVLEIAQIVWPGPLTFVLKKTERVPKEVTAGLDTVAVRMPAHPIALQLIRESGVPIAAPSANLATRPSPTKAEDVIVDLNGRVDVIIDGGHTFFGVESTIINVTVEPPVLLRPGPFTIEELKKLFGEIVIPEFAQGKKEAEIALAPGMKYKHYAPNTRLLLVENRNIFKDVVSLLSKKYKVALLIPKELSKEFEGLQQIILGSDENLYEVARNLFDSFRELDKLNVDLGIMIGFPERGIGFAIMNRARKASGFSIIKAISDVYKYVNI
Comments:
Sua5 is found in genome of all three domains of life. This protein binds threonine, ATP and U36A37-containing tRNA. Together with several other proteins of the so-called EKC/KEOPS complex, ATP, threonine and bicarbonate as cofactors, they catalyze the in vivo formation of t6A (threonyl-carbamoylation) at position 37 of all eukaryotic tRNA decoding ANN codons (ile, Met, Thr, Lys, Asn, Arg and Ser). However the detailed stepwise mechanism of t6A formation is still not known (March 2012).
Alpha Fold Predicted Structure:
Parsing response... [321288/321288]
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Protein sequence:
M
T
Q
I
I
K
I
D
P
L
N
P
E
I
D
K
I
K
I
A
A
D
V
I
R
N
G
G
T
V
A
F
P
T
E
T
V
Y
G
L
G
A
N
A
F
D
G
N
A
C
L
K
I
F
Q
A
K
N
R
P
V
D
N
P
L
I
V
H
I
A
D
F
N
Q
L
F
E
V
A
K
D
I
P
D
K
V
L
E
I
A
Q
I
V
W
P
G
P
L
T
F
V
L
K
K
T
E
R
V
P
K
E
V
T
A
G
L
D
T
V
A
V
R
M
P
A
H
P
I
A
L
Q
L
I
R
E
S
G
V
P
I
A
A
P
S
A
N
L
A
T
R
P
S
P
T
K
A
E
D
V
I
V
D
L
N
G
R
V
D
V
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I
D
G
G
H
T
F
F
G
V
E
S
T
I
I
N
V
T
V
E
P
P
V
L
L
R
P
G
P
F
T
I
E
E
L
K
K
L
F
G
E
I
V
I
P
E
F
A
Q
G
K
K
E
A
E
I
A
L
A
P
G
M
K
Y
K
H
Y
A
P
N
T
R
L
L
L
V
E
N
R
N
I
F
K
D
V
V
S
L
L
S
K
K
Y
K
V
A
L
L
I
P
K
E
L
S
K
E
F
E
G
L
Q
Q
I
I
L
G
S
D
E
N
L
Y
E
V
A
R
N
L
F
D
S
F
R
E
L
D
K
L
N
V
D
L
G
I
M
I
G
F
P
E
R
G
I
G
F
A
I
M
N
R
A
R
K
A
S
G
F
S
I
I
K
A
I
S
D
V
Y
K
Y
V
N
I
50 100 150 200 250 300 350 Sequence G H T B S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications: