ID Card:
Full name:
Threonylcarbamoyl-AMP synthase
Synonym:
YrdC, STK_15260
GI:
15921819
COG:
COG0009
UniProt:
Q970S6
Structures:
|
3AJE |
2EQA |
4E1B |
Alpha Fold Predicted Structure:
AF-Q970S6-F1
Complex:
EKC/KEOPS
Enzyme type:
threonylcarbamoyladenosine synthetase predicted
Position of modification - modification:
t :37 - t6A
PDB Structures:
3AJE
2EQA
4E1B
}
3AJE
Structure Description:
Abstract of the PDB Structure's related Publication:
Download RCSB-PDB Structures:
Protein sequence:
MTQIIKIDPLNPEIDKIKIAADVIRNGGTVAFPTETVYGLGANAFDGNACLKIFQAKNRPVDNPLIVHIADFNQLFEVAKDIPDKVLEIAQIVWPGPLTFVLKKTERVPKEVTAGLDTVAVRMPAHPIALQLIRESGVPIAAPSANLATRPSPTKAEDVIVDLNGRVDVIIDGGHTFFGVESTIINVTVEPPVLLRPGPFTIEELKKLFGEIVIPEFAQGKKEAEIALAPGMKYKHYAPNTRLLLVENRNIFKDVVSLLSKKYKVALLIPKELSKEFEGLQQIILGSDENLYEVARNLFDSFRELDKLNVDLGIMIGFPERGIGFAIMNRARKASGFSIIKAISDVYKYVNI
Comments:
Sua5 is found in genome of all three domains of life. This protein binds threonine, ATP and U36A37-containing tRNA. Together with several other proteins of the so-called EKC/KEOPS complex, ATP, threonine and bicarbonate as cofactors, they catalyze the in vivo formation of t6A (threonyl-carbamoylation) at position 37 of all eukaryotic tRNA decoding ANN codons (ile, Met, Thr, Lys, Asn, Arg and Ser). However the detailed stepwise mechanism of t6A formation is still not known (March 2012).
Alpha Fold Predicted Structure:
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Protein sequence:
M
T
Q
I
I
K
I
D
P
L
N
P
E
I
D
K
I
K
I
A
A
D
V
I
R
N
G
G
T
V
A
F
P
T
E
T
V
Y
G
L
G
A
N
A
F
D
G
N
A
C
L
K
I
F
Q
A
K
N
R
P
V
D
N
P
L
I
V
H
I
A
D
F
N
Q
L
F
E
V
A
K
D
I
P
D
K
V
L
E
I
A
Q
I
V
W
P
G
P
L
T
F
V
L
K
K
T
E
R
V
P
K
E
V
T
A
G
L
D
T
V
A
V
R
M
P
A
H
P
I
A
L
Q
L
I
R
E
S
G
V
P
I
A
A
P
S
A
N
L
A
T
R
P
S
P
T
K
A
E
D
V
I
V
D
L
N
G
R
V
D
V
I
I
D
G
G
H
T
F
F
G
V
E
S
T
I
I
N
V
T
V
E
P
P
V
L
L
R
P
G
P
F
T
I
E
E
L
K
K
L
F
G
E
I
V
I
P
E
F
A
Q
G
K
K
E
A
E
I
A
L
A
P
G
M
K
Y
K
H
Y
A
P
N
T
R
L
L
L
V
E
N
R
N
I
F
K
D
V
V
S
L
L
S
K
K
Y
K
V
A
L
L
I
P
K
E
L
S
K
E
F
E
G
L
Q
Q
I
I
L
G
S
D
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N
L
Y
E
V
A
R
N
L
F
D
S
F
R
E
L
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K
L
N
V
D
L
G
I
M
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G
F
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G
I
G
F
A
I
M
N
R
A
R
K
A
S
G
F
S
I
I
K
A
I
S
D
V
Y
K
Y
V
N
I
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
Crystal structure of Sulfolobus tokodaii Sua5 complexed with L-threonine and AMPPNP.
Kuratani M, Kasai T, Akasaka R, Higashijima K, Terada T, Kigawa T, Shinkai A, Bessho Y, Yokoyama S
Proteins
[details]
21538543
-
X-ray crystal structure of a hypothetical Sua5 protein from Sulfolobus tokodaii strain 7.
Agari Y, Sato S, Wakamatsu T, Bessho Y, Ebihara A, Yokoyama S, Kuramitsu S, Shinkai A
Proteins
[details]
18004774
-