TrmG10 it is the homolog of yeast Trm11. It catalyses formation of m2G10 or m2,2G10, depending on tRNA substrate. The activity was tested on heterologous substrates.
N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota.
N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota.
THUMP from archaeal tRNA:m22G10 methyltransferase, a genuine autonomously folding domain.