Modomics - A Database of RNA Modifications

Full name:	tRNA (guanine-N(7)-)-methyltransferase
Synonym:	ytmQ
GI:	14194920
Orf:
COG:	COG0220
UniProt:	O34522
Structures:	\| 2FCA \|
Complex:
Enzyme type:	methyltransferase
Position of modification - modification:	t:46 - m7G

Comments:

AdoMet is the methyl group donor. The activity was tested in vitro on tRNAPhe transctipt.

Protein sequence:

MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIEVGTGKGQFISGMAKQNPDINYIGIEL FKSVIVTAVQKVKDSEAQNVKLLNIDADTLTDVFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYE EVMGKGGSIHFKTDNRGLFEYSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVE WRT

Enzymatic activities:

Reaction	Substrate	Type	Position
G:m7G	tRNA (t)	Phe/#AA/prokaryotic cytosol	46

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Crystal structure of Bacillus subtilis TrmB, the tRNA (m7G46) methyltransferase.	Zegers I, Gigot D, van Vliet F, Tricot C, Aymerich S, Bujnicki JM, Kosinski J, Droogmans L	Nucleic Acids Res	[details]	16600901	-

Links:

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