ID Card:
Protein sequence:
MPLVLFTGYPCSGKTTLAKHLVQLLQSKIDATPSLSKYSITYHSDESLGIKHSDYITSQDERKLRSEIISAVKRDLSKNKIVIVDSLNYIKGFRYQLHCEVKNLSTTFCVIQTLCPPETIFEWNKTSNPNPWEPELLNQLIQRYEEPNSSNRWDSPLFAILTPQDNITDYIDDICKVVFQTSKSAKNSGHNDPLSKGLQKPNSATVLKPASQSNFIQVLDIETSKIIKTIMNHIKSLTSIGGVSNGTRVIVSEGITDINDDGCFFVDLPIGNVVTLAQLQRLKRQFINFNKLRDIDQDRIGPLFADYLNKNLN
Comments:
One of the many protein cofactors required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA. The enzyme that catalyzes this reaction is still unknown (2012).
Alpha Fold Predicted Structure:
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Protein sequence:
M
P
L
V
L
F
T
G
Y
P
C
S
G
K
T
T
L
A
K
H
L
V
Q
L
L
Q
S
K
I
D
A
T
P
S
L
S
K
Y
S
I
T
Y
H
S
D
E
S
L
G
I
K
H
S
D
Y
I
T
S
Q
D
E
R
K
L
R
S
E
I
I
S
A
V
K
R
D
L
S
K
N
K
I
V
I
V
D
S
L
N
Y
I
K
G
F
R
Y
Q
L
H
C
E
V
K
N
L
S
T
T
F
C
V
I
Q
T
L
C
P
P
E
T
I
F
E
W
N
K
T
S
N
P
N
P
W
E
P
E
L
L
N
Q
L
I
Q
R
Y
E
E
P
N
S
S
N
R
W
D
S
P
L
F
A
I
L
T
P
Q
D
N
I
T
D
Y
I
D
D
I
C
K
V
V
F
Q
T
S
K
S
A
K
N
S
G
H
N
D
P
L
S
K
G
L
Q
K
P
N
S
A
T
V
L
K
P
A
S
Q
S
N
F
I
Q
V
L
D
I
E
T
S
K
I
I
K
T
I
M
N
H
I
K
S
L
T
S
I
G
G
V
S
N
G
T
R
V
I
V
S
E
G
I
T
D
I
N
D
D
G
C
F
F
V
D
L
P
I
G
N
V
V
T
L
A
Q
L
Q
R
L
K
R
Q
F
I
N
F
N
K
L
R
D
I
D
Q
D
R
I
G
P
L
F
A
D
Y
L
N
K
N
L
N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae.
Huang B, Lu J, Bystrom AS
RNA
[details]
18755837
-
An early step in wobble uridine tRNA modification requires the Elongator complex.
Huang B, Johansson MJ, Bystrom AS
RNA
[details]
15769872
-
Links: