ID Card:
Protein sequence:
MSGSFWKFGQDYSIESPVSKILNSAFIKINKDQDDDVPTGTCEENIADDEDNSSHDYAASEDNVVNENEEKEEENTLPTTESEYENYRPNLDVLDDLLDDDELYTELMCSNFKLLIFLKYPDVLSKLIEYVTNEKILDEETDSAKKPEIIEGVNDHPILIERDRKDKKEDAEEGGDSEETTNDSDHDSGDERSVDSEETSITLPPESEEQVETRRARIAAEILSADVWPISAAIMQNKDLLGRLWSILDHPAPLPIPASTYFMKINERLLDMDITGMLEFILSRDSLVARFLTHVDNPSLMDFLLKVISTDKPDSPTGVIKILKSQELIPKLLDHLNPEYGISTQSAAGDFIKAFVTLSTNSSNELASGIGPNELTRQLVSEEMIEKLIKIMLKGGTSLSNGVGIIIELIRKNNSDYDFIQLVYTTLESHPPTDRDPIHLIHLVKLFAKHMPDFADMLDKTKLPLMEMPFGNIEPLGFERFKICELIAELLHCSNMTLLNEPNGEMIAQERDIERAKELETSTEKENITAIVDNKSSYYDKDCVEKDITENLGALQINNQGSEEDELNDTGVSSVKLDVKSDAKVVEGLENDASGVELYDETLSDTESVRECLREKPLVGDRLKIALEDTKILISILDMFTEFPWNNFLHNVIFDIAQQIFNGPLKTGYNRFLLKDYLVDAYLTKKIVDADKACQDYEKKTGLRYGYMGHLTLVAEEISKFKEYIDEMKLTFCNTAVSDRLEEPFWKEYSETILADTREKYNTVLGDFGNDQESDDDVIRNSDSEDIIGDTEGNENYGNGENDELLSNGHDSGNMDLYYNFNNNENEENEEDYAEYSDVDNKNYYNNVETNDDDYDSDDGKSKSAESEFTDKISEHRDGNSLYNEDNDENGSDKWTSGTSLFPPDHFPSRSQPSDPKLQDQNIFHHQFDFEGVGDDDDYMDPNDDGQSYARPGNPLYTTPKTPPRPKTILFNSLSALDNNGEDEEVALGTSVDDRMDNEISSDEEDSEDEDEENDMGNEEGYSLYRSRSKEAF
Comments:
One of protein cofactors required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA. The enzyme that catalyzes the reaction is still unknown.
Alpha Fold Predicted Structure:
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Protein sequence:
M
S
G
S
F
W
K
F
G
Q
D
Y
S
I
E
S
P
V
S
K
I
L
N
S
A
F
I
K
I
N
K
D
Q
D
D
D
V
P
T
G
T
C
E
E
N
I
A
D
D
E
D
N
S
S
H
D
Y
A
A
S
E
D
N
V
V
N
E
N
E
E
K
E
E
E
N
T
L
P
T
T
E
S
E
Y
E
N
Y
R
P
N
L
D
V
L
D
D
L
L
D
D
D
E
L
Y
T
E
L
M
C
S
N
F
K
L
L
I
F
L
K
Y
P
D
V
L
S
K
L
I
E
Y
V
T
N
E
K
I
L
D
E
E
T
D
S
A
K
K
P
E
I
I
E
G
V
N
D
H
P
I
L
I
E
R
D
R
K
D
K
K
E
D
A
E
E
G
G
D
S
E
E
T
T
N
D
S
D
H
D
S
G
D
E
R
S
V
D
S
E
E
T
S
I
T
L
P
P
E
S
E
E
Q
V
E
T
R
R
A
R
I
A
A
E
I
L
S
A
D
V
W
P
I
S
A
A
I
M
Q
N
K
D
L
L
G
R
L
W
S
I
L
D
H
P
A
P
L
P
I
P
A
S
T
Y
F
M
K
I
N
E
R
L
L
D
M
D
I
T
G
M
L
E
F
I
L
S
R
D
S
L
V
A
R
F
L
T
H
V
D
N
P
S
L
M
D
F
L
L
K
V
I
S
T
D
K
P
D
S
P
T
G
V
I
K
I
L
K
S
Q
E
L
I
P
K
L
L
D
H
L
N
P
E
Y
G
I
S
T
Q
S
A
A
G
D
F
I
K
A
F
V
T
L
S
T
N
S
S
N
E
L
A
S
G
I
G
P
N
E
L
T
R
Q
L
V
S
E
E
M
I
E
K
L
I
K
I
M
L
K
G
G
T
S
L
S
N
G
V
G
I
I
I
E
L
I
R
K
N
N
S
D
Y
D
F
I
Q
L
V
Y
T
T
L
E
S
H
P
P
T
D
R
D
P
I
H
L
I
H
L
V
K
L
F
A
K
H
M
P
D
F
A
D
M
L
D
K
T
K
L
P
L
M
E
M
P
F
G
N
I
E
P
L
G
F
E
R
F
K
I
C
E
L
I
A
E
L
L
H
C
S
N
M
T
L
L
N
E
P
N
G
E
M
I
A
Q
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D
I
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R
A
K
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L
E
T
S
T
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K
E
N
I
T
A
I
V
D
N
K
S
S
Y
Y
D
K
D
C
V
E
K
D
I
T
E
N
L
G
A
L
Q
I
N
N
Q
G
S
E
E
D
E
L
N
D
T
G
V
S
S
V
K
L
D
V
K
S
D
A
K
V
V
E
G
L
E
N
D
A
S
G
V
E
L
Y
D
E
T
L
S
D
T
E
S
V
R
E
C
L
R
E
K
P
L
V
G
D
R
L
K
I
A
L
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D
T
K
I
L
I
S
I
L
D
M
F
T
E
F
P
W
N
N
F
L
H
N
V
I
F
D
I
A
Q
Q
I
F
N
G
P
L
K
T
G
Y
N
R
F
L
L
K
D
Y
L
V
D
A
Y
L
T
K
K
I
V
D
A
D
K
A
C
Q
D
Y
E
K
K
T
G
L
R
Y
G
Y
M
G
H
L
T
L
V
A
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I
S
K
F
K
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Y
I
D
E
M
K
L
T
F
C
N
T
A
V
S
D
R
L
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P
F
W
K
E
Y
S
E
T
I
L
A
D
T
R
E
K
Y
N
T
V
L
G
D
F
G
N
D
Q
E
S
D
D
D
V
I
R
N
S
D
S
E
D
I
I
G
D
T
E
G
N
E
N
Y
G
N
G
E
N
D
E
L
L
S
N
G
H
D
S
G
N
M
D
L
Y
Y
N
F
N
N
N
E
N
E
E
N
E
E
D
Y
A
E
Y
S
D
V
D
N
K
N
Y
Y
N
N
V
E
T
N
D
D
D
Y
D
S
D
D
G
K
S
K
S
A
E
S
E
F
T
D
K
I
S
E
H
R
D
G
N
S
L
Y
N
E
D
N
D
E
N
G
S
D
K
W
T
S
G
T
S
L
F
P
P
D
H
F
P
S
R
S
Q
P
S
D
P
K
L
Q
D
Q
N
I
F
H
H
Q
F
D
F
E
G
V
G
D
D
D
D
Y
M
D
P
N
D
D
G
Q
S
Y
A
R
P
G
N
P
L
Y
T
T
P
K
T
P
P
R
P
K
T
I
L
F
N
S
L
S
A
L
D
N
N
G
E
D
E
E
V
A
L
G
T
S
V
D
D
R
M
D
N
E
I
S
S
D
E
E
D
S
E
D
E
D
E
E
N
D
M
G
N
E
E
G
Y
S
L
Y
R
S
R
S
K
E
A
F
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae.
Huang B, Lu J, Bystrom AS
RNA
[details]
18755837
-