Full name: SIT4-associating protein SAP190
Synonym:
GI: 330443662
Orf:
COG: COG2253
UniProt: P36123
Structures: | |
Complex:
Enzyme type: thiolase
Position of modification - modification:

Comments:

One of protein cofactors required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA. The enzyme that catalyzes the reaction is still unknown.

Protein sequence:

MSGSFWKFGQDYSIESPVSKILNSAFIKINKDQDDDVPTGTCEENIADDEDNSSHDYAASEDNVVNENEE KEEENTLPTTESEYENYRPNLDVLDDLLDDDELYTELMCSNFKLLIFLKYPDVLSKLIEYVTNEKILDEE TDSAKKPEIIEGVNDHPILIERDRKDKKEDAEEGGDSEETTNDSDHDSGDERSVDSEETSITLPPESEEQ VETRRARIAAEILSADVWPISAAIMQNKDLLGRLWSILDHPAPLPIPASTYFMKINERLLDMDITGMLEF ILSRDSLVARFLTHVDNPSLMDFLLKVISTDKPDSPTGVIKILKSQELIPKLLDHLNPEYGISTQSAAGD FIKAFVTLSTNSSNELASGIGPNELTRQLVSEEMIEKLIKIMLKGGTSLSNGVGIIIELIRKNNSDYDFI QLVYTTLESHPPTDRDPIHLIHLVKLFAKHMPDFADMLDKTKLPLMEMPFGNIEPLGFERFKICELIAEL LHCSNMTLLNEPNGEMIAQERDIERAKELETSTEKENITAIVDNKSSYYDKDCVEKDITENLGALQINNQ GSEEDELNDTGVSSVKLDVKSDAKVVEGLENDASGVELYDETLSDTESVRECLREKPLVGDRLKIALEDT KILISILDMFTEFPWNNFLHNVIFDIAQQIFNGPLKTGYNRFLLKDYLVDAYLTKKIVDADKACQDYEKK TGLRYGYMGHLTLVAEEISKFKEYIDEMKLTFCNTAVSDRLEEPFWKEYSETILADTREKYNTVLGDFGN DQESDDDVIRNSDSEDIIGDTEGNENYGNGENDELLSNGHDSGNMDLYYNFNNNENEENEEDYAEYSDVD NKNYYNNVETNDDDYDSDDGKSKSAESEFTDKISEHRDGNSLYNEDNDENGSDKWTSGTSLFPPDHFPSR SQPSDPKLQDQNIFHHQFDFEGVGDDDDYMDPNDDGQSYARPGNPLYTTPKTPPRPKTILFNSLSALDNN GEDEEVALGTSVDDRMDNEISSDEEDSEDEDEENDMGNEEGYSLYRSRSKEAF

Publications:

Title Authors Journal Details PubMed Id DOI
A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae. Huang B, Lu J, Bystrom AS RNA [details] 18755837 -
Copyright © Genesilico - All rights reserved
If you have any advice or suggestions for corrections or improvements, please contact: Pietro Boccaletto