ID Card:
Full name:
Serine/threonine-protein phosphatase PP1-1
Synonym:
PPH1
GI:
6320156
Orf:
D2693
COG:
COG0639
UniProt:
P20604
Alpha Fold Predicted Structure:
AF-P20604-F1
Enzyme type:
phosphatase
Protein sequence:
MVSRGPDEWLETIKKCQALTENEMKQLCEMVKELLMEESNIQPVQTPVTVCGDIHGQFHDLLELFRTAGGFPDDINYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQITQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDNVEAWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFSAVPDDYIRESTANHNNQRAGYFL
Comments:
One of protein cofactors required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA. The enzyme that catalyzes the reaction is still unknown.
Alpha Fold Predicted Structure:
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Protein sequence:
M
V
S
R
G
P
D
E
W
L
E
T
I
K
K
C
Q
A
L
T
E
N
E
M
K
Q
L
C
E
M
V
K
E
L
L
M
E
E
S
N
I
Q
P
V
Q
T
P
V
T
V
C
G
D
I
H
G
Q
F
H
D
L
L
E
L
F
R
T
A
G
G
F
P
D
D
I
N
Y
I
F
L
G
D
Y
V
D
R
G
Y
Y
S
L
E
T
F
T
L
L
M
C
L
K
V
K
Y
P
A
K
I
T
L
V
R
G
N
H
E
S
R
Q
I
T
Q
V
Y
G
F
Y
E
E
C
L
N
K
Y
G
S
T
T
V
W
K
Y
C
C
Q
V
F
D
F
L
T
L
A
A
I
I
D
G
K
I
L
C
V
H
G
G
L
S
P
E
I
R
M
L
D
Q
I
R
V
L
S
R
A
Q
E
V
P
H
E
G
G
F
S
D
L
L
W
S
D
P
D
N
V
E
A
W
Q
V
S
P
R
G
A
G
W
L
F
G
S
K
V
A
R
E
F
N
H
V
N
G
L
N
L
I
A
R
A
H
Q
L
V
M
E
G
F
K
Y
H
F
P
E
K
D
V
V
T
V
W
S
A
P
N
Y
C
Y
R
C
G
N
V
A
S
V
M
K
V
D
E
D
L
E
P
T
F
K
I
F
S
A
V
P
D
D
Y
I
R
E
S
T
A
N
H
N
N
Q
R
A
G
Y
F
L
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae.
Huang B, Lu J, Bystrom AS
RNA
[details]
18755837
-