ID Card:
Full name:
RNA-capping enzyme
Synonym:
HCE, mRNA 5'-triphosphatase, GTP--RNA guanylyltransferase
GI:
6685628
Orf:
RNGTT
COG:
COG5226
UniProt:
O60942
Structures:
|
3S24 |
2C46 |
Alpha Fold Predicted Structure:
AF-O60942-F1
Enzyme type:
triphosphatase, guanylyltransferase
Position of modification - modification:
m :0 - m7GpppN
PDB Structures:
3S24
2C46
}
3S24
Structure Description:
Title:
CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase
Classification:
TRANSFERASE
X-Ray Diffraction
1.60
0.234
0.206
0.204
Abstract of the PDB Structure's related Publication:
Download RCSB-PDB Structures:
Protein sequence:
MAHNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVKMGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNPPELIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRRYGDIEEAPPPPLLPDWCFEDDEDEDEDEDGKKESEPGSSASFGKRRKERLKLGAIFLEGVTVKGVTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPVSMDKQNIKLLDLKPYKVSWKADGTRYMMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSNTLLDGEMIIDRVNGQAVPRYLIYDIIKFNSQPVGDCDFNVRLQCIEREIISPRHEKMKTGLIDKTQEPFSVRNKPFFDICTSRKLLEGNFAKEVSHEMDGLIFQPTGKYKPGRCDDILKWKPPSLNSVDFRLKITRMGGEGLLPQNVGLLYVGGYERPFAQIKVTKELKQYDNKIIECKFENNSWVFMRQRTDKSFPNAYNTAMAVCNSISNPVTKEMLFEFIDRCTAASQGQKRKHHLDPDTELMPPPPPKRPRPLT
Comments:
Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part.
Alpha Fold Predicted Structure:
Downloading... [93946/552503]
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Protein sequence:
M
A
H
N
K
I
P
P
R
W
L
N
C
P
R
R
G
Q
P
V
A
G
R
F
L
P
L
K
T
M
L
G
P
R
Y
D
S
Q
V
A
E
E
N
R
F
H
P
S
M
L
S
N
Y
L
K
S
L
K
V
K
M
G
L
L
V
D
L
T
N
T
S
R
F
Y
D
R
N
D
I
E
K
E
G
I
K
Y
I
K
L
Q
C
K
G
H
G
E
C
P
T
T
E
N
T
E
T
F
I
R
L
C
E
R
F
N
E
R
N
P
P
E
L
I
G
V
H
C
T
H
G
F
N
R
T
G
F
L
I
C
A
F
L
V
E
K
M
D
W
S
I
E
A
A
V
A
T
F
A
Q
A
R
P
P
G
I
Y
K
G
D
Y
L
K
E
L
F
R
R
Y
G
D
I
E
E
A
P
P
P
P
L
L
P
D
W
C
F
E
D
D
E
D
E
D
E
D
E
D
G
K
K
E
S
E
P
G
S
S
A
S
F
G
K
R
R
K
E
R
L
K
L
G
A
I
F
L
E
G
V
T
V
K
G
V
T
Q
V
T
T
Q
P
K
L
G
E
V
Q
Q
K
C
H
Q
F
C
G
W
E
G
S
G
F
P
G
A
Q
P
V
S
M
D
K
Q
N
I
K
L
L
D
L
K
P
Y
K
V
S
W
K
A
D
G
T
R
Y
M
M
L
I
D
G
T
N
E
V
F
M
I
D
R
D
N
S
V
F
H
V
S
N
L
E
F
P
F
R
K
D
L
R
M
H
L
S
N
T
L
L
D
G
E
M
I
I
D
R
V
N
G
Q
A
V
P
R
Y
L
I
Y
D
I
I
K
F
N
S
Q
P
V
G
D
C
D
F
N
V
R
L
Q
C
I
E
R
E
I
I
S
P
R
H
E
K
M
K
T
G
L
I
D
K
T
Q
E
P
F
S
V
R
N
K
P
F
F
D
I
C
T
S
R
K
L
L
E
G
N
F
A
K
E
V
S
H
E
M
D
G
L
I
F
Q
P
T
G
K
Y
K
P
G
R
C
D
D
I
L
K
W
K
P
P
S
L
N
S
V
D
F
R
L
K
I
T
R
M
G
G
E
G
L
L
P
Q
N
V
G
L
L
Y
V
G
G
Y
E
R
P
F
A
Q
I
K
V
T
K
E
L
K
Q
Y
D
N
K
I
I
E
C
K
F
E
N
N
S
W
V
F
M
R
Q
R
T
D
K
S
F
P
N
A
Y
N
T
A
M
A
V
C
N
S
I
S
N
P
V
T
K
E
M
L
F
E
F
I
D
R
C
T
A
A
S
Q
G
Q
K
R
K
H
H
L
D
P
D
T
E
L
M
P
P
P
P
P
K
R
P
R
P
L
T
50 100 150 200 250 300 350 400 450 500 550 Sequence G H I T B S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
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