ID Card:
Full name:
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
Synonym:
hMTr2, FTSJD1, FLJ11171
GI:
269849596
Orf:
FTSJD1, FLJ11171
COG:
COG0293
UniProt:
Q8IYT2
Alpha Fold Predicted Structure:
AF-Q8IYT2-F1
Enzyme type:
methyltransferase
Position of modification - modification:
m :2 - GpppNNm
m :2 - GpppNmNm
m :2 - m7GpppNNm
m :2 - m7GpppNmNm
n :2 - GpppNNm
n :2 - GpppNmNm
n :2 - m7GpppNNm
n :2 - m7GpppNmNm
Protein sequence:
MSKCRKTPVQQLASPASFSPDILADIFELFAKNFSYGKPLNNEWQLPDPSEIFTCDHTELNAFLDLKNSLNEVKNLLSDKKLDEWHEHTAFTNKAGKIISHVRKSVNAELCTQAWCKFHEILCSFPLIPQEAFQNGKLNSLHLCEAPGAFIASLNHYLKSHRFPCHWSWVANTLNPYHEANDDLMMIMDDRLIANTLHWWYFGPDNTGDIMTLKFLTGLQNFISSMATVHLVTADGSFDCQGNPGEQEALVSSLHYCEVVTALTTLGNGGSFVLKMFTMFEHCSINLMYLLNCCFDQVHVFKPATSKAGNSEVYVVCLHYKGREAIHPLLSKMTLNFGTEMKRKALFPHHVIPDSFLKRHEECCVFFHKYQLETISENIRLFECMGKAEQEKLNNLRDCAIQYFMQKFQLKHLSRNNWLVKKSSIGCSTNTKWFGQRNKYFKTYNERKMLEALSWKDKVAKGYFNSWAEEHGVYHPGQSSILEGTASNLECHLWHILEGKKLPKVKCSPFCNGEILKTLNEAIEKSLGGAFNLDSKFRPKQQYSCSCHVFSEELIFSELCSLTECLQDEQVVVPSNQIKCLLVGFSTLRNIKMHIPLEVRLLESAELTTFSCSLLHDGDPTYQRLFLDCLLHSLRELHTGDVMILPVLSCFTRFMAGLIFVLHSCFRFITFVCPTSSDPLRTCAVLLCVGYQDLPNPVFRYLQSVNELLSTLLNSDSPQQVLQFVPMEVLLKGALLDFLWDLNAAIAKRHLHFIIQREREEIINSLQLQN
Comments:
hMTr2 protein transfers a methyl group from S-adenosylmethionine to the 2'-O-ribose of the second nucleotide of messenger RNA and small nuclear RNA. Neither N(7) methylation of the guanosine cap nor 2'-O-ribose methylation of the first transcribed nucleotide are required for hMTr2, but the presence of cap1 methylation increases hMTr2 activity. The hMTr2 protein is distributed throughout the nucleus and cytosol, in contrast to the nuclear hMTr1.
Alpha Fold Predicted Structure:
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Protein sequence:
M
S
K
C
R
K
T
P
V
Q
Q
L
A
S
P
A
S
F
S
P
D
I
L
A
D
I
F
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L
F
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F
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N
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P
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F
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N
A
F
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V
K
N
L
L
S
D
K
K
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D
E
W
H
E
H
T
A
F
T
N
K
A
G
K
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N
A
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M
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A
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N
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L
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A
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N
100 200 300 400 500 600 700 Sequence G H T B S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
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