ID Card:
Full name:
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
Synonym:
hMTr2, FTSJD1, FLJ11171
GI:
269849596
Orf:
FTSJD1, FLJ11171
COG:
COG0293
UniProt:
Q8IYT2
Alpha Fold Predicted Structure:
AF-Q8IYT2-F1
Enzyme type:
methyltransferase
Position of modification - modification:
m :2 - GpppNNm
m :2 - GpppNmNm
m :2 - m7GpppNNm
m :2 - m7GpppNmNm
n :2 - GpppNNm
n :2 - GpppNmNm
n :2 - m7GpppNNm
n :2 - m7GpppNmNm
Protein sequence:
MSKCRKTPVQQLASPASFSPDILADIFELFAKNFSYGKPLNNEWQLPDPSEIFTCDHTELNAFLDLKNSLNEVKNLLSDKKLDEWHEHTAFTNKAGKIISHVRKSVNAELCTQAWCKFHEILCSFPLIPQEAFQNGKLNSLHLCEAPGAFIASLNHYLKSHRFPCHWSWVANTLNPYHEANDDLMMIMDDRLIANTLHWWYFGPDNTGDIMTLKFLTGLQNFISSMATVHLVTADGSFDCQGNPGEQEALVSSLHYCEVVTALTTLGNGGSFVLKMFTMFEHCSINLMYLLNCCFDQVHVFKPATSKAGNSEVYVVCLHYKGREAIHPLLSKMTLNFGTEMKRKALFPHHVIPDSFLKRHEECCVFFHKYQLETISENIRLFECMGKAEQEKLNNLRDCAIQYFMQKFQLKHLSRNNWLVKKSSIGCSTNTKWFGQRNKYFKTYNERKMLEALSWKDKVAKGYFNSWAEEHGVYHPGQSSILEGTASNLECHLWHILEGKKLPKVKCSPFCNGEILKTLNEAIEKSLGGAFNLDSKFRPKQQYSCSCHVFSEELIFSELCSLTECLQDEQVVVPSNQIKCLLVGFSTLRNIKMHIPLEVRLLESAELTTFSCSLLHDGDPTYQRLFLDCLLHSLRELHTGDVMILPVLSCFTRFMAGLIFVLHSCFRFITFVCPTSSDPLRTCAVLLCVGYQDLPNPVFRYLQSVNELLSTLLNSDSPQQVLQFVPMEVLLKGALLDFLWDLNAAIAKRHLHFIIQREREEIINSLQLQN
Comments:
hMTr2 protein transfers a methyl group from S-adenosylmethionine to the 2'-O-ribose of the second nucleotide of messenger RNA and small nuclear RNA. Neither N(7) methylation of the guanosine cap nor 2'-O-ribose methylation of the first transcribed nucleotide are required for hMTr2, but the presence of cap1 methylation increases hMTr2 activity. The hMTr2 protein is distributed throughout the nucleus and cytosol, in contrast to the nuclear hMTr1.
ID
Reaction
Substrate
SubstrateType
Transcript Name
Transcript Region
Cellular Localization
References
GpppNN:GpppNNm RNA
snRNA
2
small nuclear RNA component of U2 snRNP
capG : cap2
Cytoplasm and Nucleoplasm
21310715
GpppNN:GpppNNm RNA
mRNA
2
capG : cap2
Cytoplasm and Nucleoplasm
21310715
m7GpppNN:m7GpppNNm RNA
snRNA
2
small nuclear RNA component of U2 snRNP
capG : cap2
Cytoplasm and Nucleoplasm
21310715
m7GpppNN:m7GpppNNm RNA
mRNA
2
capG : cap2
Cytoplasm and Nucleoplasm
21310715
GpppNmN:GpppNmNm RNA
snRNA
2
small nuclear RNA component of U2 snRNP
capG : cap2
Cytoplasm and Nucleoplasm
21310715
GpppNmN:GpppNmNm RNA
mRNA
2
capG : cap2
Cytoplasm and Nucleoplasm
21310715
m7GpppNmN:GpppNmNm RNA
snRNA
2
small nuclear RNA component of U2 snRNP
capG : cap2
Cytoplasm and Nucleoplasm
21310715
m7GpppNmN:m7GpppNmNm RNA
mRNA
2
capG : cap2
Cytoplasm and Nucleoplasm
21310715
Alpha Fold Predicted Structure:
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Protein sequence:
M
S
K
C
R
K
T
P
V
Q
Q
L
A
S
P
A
S
F
S
P
D
I
L
A
D
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F
E
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K
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F
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G
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N
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W
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D
P
S
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F
T
C
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H
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N
A
F
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N
S
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N
E
V
K
N
L
L
S
D
K
K
L
D
E
W
H
E
H
T
A
F
T
N
K
A
G
K
I
I
S
H
V
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K
S
V
N
A
E
L
C
T
Q
A
W
C
K
F
H
E
I
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C
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F
P
L
I
P
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A
F
Q
N
G
K
L
N
S
L
H
L
C
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A
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G
A
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A
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D
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M
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M
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A
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T
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W
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F
G
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N
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G
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K
F
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G
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Q
N
F
I
S
S
M
A
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G
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N
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A
L
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A
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G
N
G
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M
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N
L
M
Y
L
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A
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A
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C
A
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F
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G
Y
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A
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G
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H
P
G
Q
S
S
I
L
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G
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A
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N
L
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L
W
H
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L
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G
K
K
L
P
K
V
K
C
S
P
F
C
N
G
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I
L
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T
L
N
E
A
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K
S
L
G
G
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N
L
D
S
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P
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S
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S
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G
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Y
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C
L
L
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L
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G
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M
I
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V
L
S
C
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M
A
G
L
I
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V
L
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S
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L
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G
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L
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L
L
N
S
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S
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Q
V
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M
E
V
L
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A
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A
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R
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S
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L
Q
N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family.
Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM
Nucleic Acids Res
[details]
21310715
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Links: