Full name: cap methyltranferase 2
Synonym: hMTr2, FTSJD1, FLJ11171
GI: 269849596
Orf: FTSJD1, FLJ11171
COG: COG0293
UniProt: Q8IYT2
Structures: | |
Complex:
Enzyme type: methyltransferase
Position of modification - modification: n:2 - m7GpppNmNm
m:2 - m7GpppNmNm

Comments:

hMTr2 protein transfers a methyl group from S-adenosylmethionine to the 2'-O-ribose of the second nucleotide of messenger RNA and small nuclear RNA. Neither N(7) methylation of the guanosine cap nor 2'-O-ribose methylation of the first transcribed nucleotide are required for hMTr2, but the presence of cap1 methylation increases hMTr2 activity. The hMTr2 protein is distributed throughout the nucleus and cytosol, in contrast to the nuclear hMTr1.

Protein sequence:

MSKCRKTPVQQLASPASFSPDILADIFELFAKNFSYGKPLNNEWQLPDPSEIFTCDHTELNAFLDLKNSL NEVKNLLSDKKLDEWHEHTAFTNKAGKIISHVRKSVNAELCTQAWCKFHEILCSFPLIPQEAFQNGKLNS LHLCEAPGAFIASLNHYLKSHRFPCHWSWVANTLNPYHEANDDLMMIMDDRLIANTLHWWYFGPDNTGDI MTLKFLTGLQNFISSMATVHLVTADGSFDCQGNPGEQEALVSSLHYCEVVTALTTLGNGGSFVLKMFTMF EHCSINLMYLLNCCFDQVHVFKPATSKAGNSEVYVVCLHYKGREAIHPLLSKMTLNFGTEMKRKALFPHH VIPDSFLKRHEECCVFFHKYQLETISENIRLFECMGKAEQEKLNNLRDCAIQYFMQKFQLKHLSRNNWLV KKSSIGCSTNTKWFGQRNKYFKTYNERKMLEALSWKDKVAKGYFNSWAEEHGVYHPGQSSILEGTASNLE CHLWHILEGKKLPKVKCSPFCNGEILKTLNEAIEKSLGGAFNLDSKFRPKQQYSCSCHVFSEELIFSELC SLTECLQDEQVVVPSNQIKCLLVGFSTLRNIKMHIPLEVRLLESAELTTFSCSLLHDGDPTYQRLFLDCL LHSLRELHTGDVMILPVLSCFTRFMAGLIFVLHSCFRFITFVCPTSSDPLRTCAVLLCVGYQDLPNPVFR YLQSVNELLSTLLNSDSPQQVLQFVPMEVLLKGALLDFLWDLNAAIAKRHLHFIIQREREEIINSLQLQN

Enzymatic activities:

Reaction Substrate Type Position
m7GpppNm:m7GpppNmNm mRNA (m) 2
m7GpppNm:m7GpppNmNm snRNA (sn) U1 2
m7GpppNm:m7GpppNmNm snRNA (sn) U2// 2
m7Gpp(pN):m7GpppNNm mRNA (m) 2
m7Gpp(pN):m7GpppNNm snRNA (sn) U1 2
m7Gpp(pN):m7GpppNNm snRNA (sn) U2// 2
Gpp(pN):GpppNNm mRNA (m) 2
Gpp(pN):GpppNNm snRNA (sn) U1 2
Gpp(pN):GpppNNm snRNA (sn) U2// 2

Publications:

Title Authors Journal Details PubMed Id DOI
2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM Nucleic Acids Res [details] 21310715 -

Links:

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