MIS complex (Mum2, Ime4, and Slz1) mediates N6-methyladenosine (m6A) methylation on some mRNAs during meiosis and
is required for sporulation, targeting 5'-[AG]GAC-3' consensus sites. Ime4 is the catalytic component of the MIS
complex (
Agarwala et al. 2012) and catalyses the AdoMet-dependent N6-methylation of internal adenosine in yeast mRNA, including mRNA coding for Ime4 (regulatory role).
Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene.
Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene.
RNA methylation by the MIS complex regulates a cell fate decision in yeast.