| Full name: |
RNA decapping complex subunit 2 |
| Synonym: |
|
| GI: |
74675930 |
| Orf: |
dcp2 |
| COG: |
COG0494 |
| UniProt: |
O13828 |
| Structures: |
|
2A6T |
|
| Complex: |
|
| Enzyme type: |
hydrolase |
| Position of modification - modification: |
|
Comments:
The Dcp2 protein removes the cap structure of mRNA by cleaving capped mRNA which allows initiating 5′ to 3′ degradation. Decapping holoenzyme is composed of the catalytic Dcp2 subunit and the coactivator Dcp1. Dcp1 and the substrate RNA promote the closed form of the enzyme and the catalytic step of decapping is rate limiting and accelerated by Dcp1.
Protein sequence:
MSFTNATFSQVLDDLSARFILNLPAEEQSSVERLCFQIEQAHWFYEDFIRAQNDQLPSLGLRVFSAKLFA
HCPLLWKWSKVHEEAFDDFLRYKTRIPVRGAIMLDMSMQQCVLVKGWKASSGWGFPKGKIDKDESDVDCA
IREVYEETGFDCSSRINPNEFIDMTIRGQNVRLYIIPGISLDTRFESRTRKEISKIEWHNLMDLPTFKKN
KPQTMKNKFYMVIPFLAPLKKWIKKRNIANNTTKEKNISVDVDADASSQLLSLLKSSTAPSDLATPQPST
FPQPPVESHSSFDIKQKILHLLNEGNEPKSPIQLPPVSNLPLNPPIQSSNSRLSHDNNSFDPFAYLGLDP
KNPSASFPRVVSQNNMLTNKPVLNNHFQQSMYSNLLKDQNSVQHLFAASDMPSPMELPSPSTVYHQVFYP
PTSTSVSSYGLGKTPQPAYGSSSPYVNGHQTQQISSLPPFQSQTQFLARNSDNSGQSYNSEGDSNSKRLL
SMLSQQDTTPSSSTLSKEANVQLANLFLTPNSLETKKFSDNSQGEEISDNLHGESCNNPNANSVHSAQLL
QALLHPSATETKEETPKKTSDSLSLLTLLKSGLPTPANDLQNKSQNNERKASSQVKELEVKNYSKSTDLL
KKTLRIPRNDEPLEAANQFDLLKVSPQQKSEVPPKRNELSQSKLKNRKKKENSETNKNHVDMSPGFVKIL
KRSPLADQKKEDTQESDFKGSDDHFLSYLQSVVSSNSNGLH
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Decapping reaction of mRNA requires Dcp1 in fission yeast: its characterization in different species from yeast to human. |
Sakuno T, Araki Y, Ohya Y, Kofuji S, Takahashi S, Hoshino S, Katada T... |
J Biochem |
[details]
|
15671491
|
-
|
Links: