Modomics - A Database of RNA Modifications
DcpS from Homo sapiens - protein summary.
Scavenger mRNA-decapping enzyme DcpS
DCS-1, Hint-related 7meGMP-directed hydrolase, HINT5
Position of modification - modification:
DcpS, catalyzes residual cap hydrolysis following mRNA degradation, releasing N-7 methyl guanosine monophosphate and 5'-diphosphate terminated cap or mRNA products. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides.
Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity.
Gu M, Fabrega C, Liu SW, Liu H, Kiledjian M, Lima CD
The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases.
Liu H, Rodgers ND, Jiao X, Kiledjian M
Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1.
Kwasnicka DA, Krakowiak A, Thacker C, Brenner C, Vincent SR
J Biol Chem
Functional link between the mammalian exosome and mRNA decapping.
Wang Z, Kiledjian M
DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway.
van Dijk E, Le Hir H, Seraphin B
Proc Natl Acad Sci U S A
Functional analysis of mRNA scavenger decapping enzymes.
Liu SW, Jiao X, Liu H, Gu M, Lima CD, Kiledjian M
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