Full name: | rRNA guanine N-1-methyltransferase |
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Synonym: | avilamycin resistance 23S rRNA methyltransferase |
GI: | 28380397 |
Orf: | aviRa |
COG: | COG1041 |
UniProt: | Q9F5K5 |
Structures: | | 1O9G | 1O9H | |
Alpha Fold Predicted Structure: | AF-Q9F5K5-F1 |
Enzyme type: | methyltransferase |
Position of modification - modification: |
l:2535(2535) - m1G |
Title: | |
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Classification: | |
Technique: | |
Pdb Files | 1O9G.pdb   1O9H.pdb   |
Pdbx/mmCIF Files | 1O9G.cif   1O9H.cif   |
MSAYRHAVERIDSSDLACGVVLHSAPGYPAFPVRLATEIFQRALARLPGDGPVTLWDPCCGSGYLLTVLGLLHRRSLRQVIASDVDPAPLELAAKNLALLSPAGLTARELERREQSERFGKPSYLEAAQAARRLRERLTAEGGALPCAIRTADVFDPRALSAVLAGSAPDVVLTDLPYGERTHWEGQVPAQPVAGLLRSLASALPAHAVIAVTDRSRKIPVAPVKALERLKIGTRSAVLVRAADVLEAGP
Methylation site was determined for E. coli rRNA.
Reaction | Substrate | SubstrateType | Position | (Anti)Codon | Modified (Anti)Codon | Amino Acid Change | Transcript Name | Transcript Region | Cellular Localization | References |
---|---|---|---|---|---|---|---|---|---|---|
G:m1G | rRNA | LSU | 2535 | LSU-23S | prokaryotic cytosol | 12828631    |
Alpha Fold Pdb Files | AF-Q9F5K5-F1.pdb   |
Alpha Fold Pdbx/mmCIF Files | AF-Q9F5K5-F1.cif   |
DSSP Secondary Structures | Q9F5K5.dssp   |
Title | Authors | Journal | Details | ||
---|---|---|---|---|---|
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose. | Treede I, Jakobsen L, Kirpekar F, Vester B, Weitnauer G, Bechthold A, Douthwaite S | Mol Microbiol | [details] | 12828631 | - |
Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes. | Mosbacher TG, Bechthold A, Schulz GE | J Mol Biol | [details] | 12742024 | - |
An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57. | Weitnauer G, Gaisser S, Trefzer A, Stockert S, Westrich L, Quiros LM, Mendez C, Salas JA, Bechthold A | Antimicrob Agents Chemother | [details] | 11181344 | - |