Full name: rRNA (uridine-2'-O-)-methyltransferase
Synonym: avilamycin resistance 23S rRNA methyltransferase
GI: 60593969
Orf: aviRb
COG: COG0566
UniProt: Q9F5K6
Structures: | 1X7O | 1X7P |
Complex:
Enzyme type: methyltransferase
Position of modification - modification: l:2479(2479) - Um

Comments:

Methylation site was determined for E. coli rRNA.

Protein sequence:

MARSRGERTPAARRITSRNARFQQWQALLGNRNKRTRAGEFLVMGVRPISLAVEHGWPVRTLLYDGQREL SKWARELLRTVRTEQIAMAPDLLMELGEKNEAPPEVVAVVEMPADDLDRIPVREDFLGVLFDRPTSPGNI GSIIRSADALGAHGLIVAGHAADVYDPKSVRSSTGSLFSLPAVRVPSPGEVMDWVEARRAAGTPIVLVGT DEHGDCDVFDFDFTQPTLLLIGNETAGLSNAWRTLCDYTVSIPMAGSASSLNAANAATAILYEAVRQRIS GRTATTP

Enzymatic activities:

Reaction Substrate Type Position
U:Um rRNA (r) LSU/23S/prokaryotic cytosol 2479

Publications:

Title Authors Journal Details PubMed Id DOI
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose. Treede I, Jakobsen L, Kirpekar F, Vester B, Weitnauer G, Bechthold A, Douthwaite S Mol Microbiol [details] 12828631 -
An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57. Weitnauer G, Gaisser S, Trefzer A, Stockert S, Westrich L, Quiros LM, Mendez C, Salas JA, Bechthold A Antimicrob Agents Chemother [details] 11181344 -
Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes. Mosbacher TG, Bechthold A, Schulz GE J Mol Biol [details] 15581897 -
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