Full name: rRNA adenine N-7-methyltransferase
Synonym: Sisomicin-gentamicin resistance methylase
GI: 75383291
Orf: sgm
COG: COG2263
UniProt: Q7M0R2
Structures: | 3LCU | 3LCV |
Complex:
Enzyme type: methyltransferase
Position of modification - modification: s:1405(1405) - m7G

Comments:

Methylation site was determined for E. coli rRNA.

Protein sequence:

MTAPAADDRIDEIERAITKSRRYQTVAPATVRRLARAALVAARGDVPDAVKRTKRGLHEIYGAFLPPSPP NYAALLRHLDSAVDAGDDEAVRAALLRAMSVHISTRERLPHLDEFYRELFRHLPRPNTLRDLACGLNPLA APWMGLPAETVYIASDIDARLVGFVDEALTRLNVPHRTNVADLLEDRLDEPADVTLLLKTLPCLETQQRG SGWEVIDIVNSPNIVVTFPTKSLGQRSKGMFQNYSQSFESQARERSCRIQRLEIGNELIYVIQK

Enzymatic activities:

Reaction Substrate Type Position
G:m7G rRNA (r) SSU/16S/prokaryotic cytosol 1405

Publications:

Title Authors Journal Details PubMed Id DOI
Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases. Husain N, Tkaczuk KL, Tulsidas SR, Kaminska KH, Cubrilo S, Maravic-Vlahovicek G, Bujnicki JM, Sivaraman J Nucleic Acids Res [details] 20194115 -
Cloning and characterization of an aminoglycoside resistance determinant from Micromonospora zionensis. Kojic M, Topisirovic L, Vasiljevic B J Bacteriol [details] 1447159 -
Critical residues for cofactor binding and catalytic activity in the aminoglycoside resistance methyltransferase Sgm. Savic M, Ilic-Tomic T, Macmaster R, Vasiljevic B, Conn GL J Bacteriol [details] 18586937 -
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