Modomics - A Database of RNA Modifications

Full name:	rRNA cytydine C-5-methyltransferase
Synonym:	kanamycin and tobramycin resistance 16S rRNA methyltransferase
GI:	383329552
Orf:	efmM
COG:
UniProt:	E9KIK3
Structures:	\| 3M4X \|
Complex:
Enzyme type:	methyltransferase
Position of modification - modification:	s:1404(1404) - m5C

Comments:

Protein sequence:

MKEEATTLPQQFIKKYRLLLGEEASDFFSALEQGSVKKGFRWNPLKPAGLDMVQTYHSEELQPAPYSNEGFLGTVNGKSFLHQAGYEYSQEPSAMIVGTA
AAAKPGEKVLDLCAAPGGKSTQLAAQMKGKGLLVTNEIFPKRAKILSENIERWGVSNAIVTNHAPAELVPHFSGFFDRIVVDAPCSGEGMFRKDPNAIKE
WTEESPLYCQKRQQEILSSAIKMLKNKGQLIYSTCTFAPEENEEIISWLVENYPVTIEEIPLTQSVSSGRSEWGSVAGLEKTIRIWPHKDQGEGHFVAKL
TFHGQNQMHKEKKTRKKSKVQMTKEQEKLWTEFSNDFHYEATGRLLVFNDHLWEVPELAPSLDGLKVVRTGLHLGDFKKNRFEPSYALALATKKIENIPC
LPITQKEWQSYTAGETFQRDGNQGWVLLVLDKIPVGFGKQVKGTVKNFFPKGLRFH

Enzymatic activities:

Reaction	Substrate	Type	Position
C:m5C	rRNA (r)	SSU/16S/prokaryotic cytosol	1404

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Intrinsic resistance to aminoglycosides in Enterococcus faecium is conferred by the 16S rRNA m5C1404-specific methyltransferase EfmM.	Galimand M, Schmitt E, Panvert M, Desmolaize B, Douthwaite S, Mechulam Y, Courvalin P	RNA	[details]	21159796	-