Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA (cytosine(34)-C(5))-methyltransferase
Synonym: hMisu, SAKI
GI: 39995082
Orf: NSUN2
COG: COG0144
UniProt: Q08J23
Alpha Fold Predicted Structure: AF-Q08J23-F1
Enzyme type: methyltransferase
Position of modification - modification: pre-tRNA:34 - m5C
m:many - m5C
other:many - m5C
t:48 - m5C
t:49 - m5C
t:50 - m5C
pre-tRNA:48 - m5C



Protein sequence:

MGRRSRGRRLQQQQRPEDAEDGAEGGGKRGEAGWEGGYPEIVKENKLFEHYYQELKIVPEGEWGQFMDALREPLPATLRITGYKSHAKEILHCLKNKYFKELEDLEVDGQKVEVPQPLSWYPEELAWHTNLSRKILRKSPHLEKFHQFLVSETESGNISRQEAVSMIPPLLLNVRPHHKILDMCAAPGSKTTQLIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLQIDVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPIEDEAVIASLLEKSEGALELADVSNELPGLKWMPGITQWKVMTKDGQWFTDWDAVPHSRHTQIRPTMFPPKDPEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKSSMPWNKRQPKLQGKSAETRESTQLSPADLTEGKPTDPSKLESPSFTGTGDTEIAHATEDLENNGSKKDGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLLNNSEKMKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINSRIITVSMEDVKILLTQENPFFRKLSSETYSQAKDLAKGSIVLKYEPDSANPDALQCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLEVLGEKKKEGVILTNESAASTGQPDNDVTEGQRAGEPNSPDAEEANSPDVTAGCDPAGVHPPR

Comments:

Multisite specific enzyme. Orthologue of yeast Trm4. It modifies not only tRNA but also RPPH1 subunit of RNase P and some mRNAs. hTrm4 partially complements the lack of the endogenous SceTrm4p. Exists in two isoforms.





Alpha Fold Predicted Structure:




Downloading... [294650/700758]


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Protein sequence:

M G R R S R G R R L Q Q Q Q R P E D A E D G A E G G G K R G E A G W E G G Y P E I V K E N K L F E H Y Y Q E L K I V P E G E W G Q F M D A L R E P L P A T L R I T G Y K S H A K E I L H C L K N K Y F K E L E D L E V D G Q K V E V P Q P L S W Y P E E L A W H T N L S R K I L R K S P H L E K F H Q F L V S E T E S G N I S R Q E A V S M I P P L L L N V R P H H K I L D M C A A P G S K T T Q L I E M L H A D M N V P F P E G F V I A N D V D N K R C Y L L V H Q A K R L S S P C I M V V N H D A S S I P R L Q I D V D G R K E I L F Y D R I L C D V P C S G D G T M R K N I D V W K K W T T L N S L Q L H G L Q L R I A T R G A E Q L A E G G R M V Y S T C S L N P I E D E A V I A S L L E K S E G A L E L A D V S N E L P G L K W M P G I T Q W K V M T K D G Q W F T D W D A V P H S R H T Q I R P T M F P P K D P E K L Q A M H L E R C L R I L P H H Q N T G G F F V A V L V K K S S M P W N K R Q P K L Q G K S A E T R E S T Q L S P A D L T E G K P T D P S K L E S P S F T G T G D T E I A H A T E D L E N N G S K K D G V C G P P P S K K M K L F G F K E D P F V F I P E D D P L F P P I E K F Y A L D P S F P R M N L L T R T T E G K K R Q L Y M V S K E L R N V L L N N S E K M K V I N T G I K V W C R N N S G E E F D C A F R L A Q E G I Y T L Y P F I N S R I I T V S M E D V K I L L T Q E N P F F R K L S S E T Y S Q A K D L A K G S I V L K Y E P D S A N P D A L Q C P I V L C G W R G K A S I R T F V P K N E R L H Y L R M M G L E V L G E K K K E G V I L T N E S A A S T G Q P D N D V T E G Q R A G E P N S P D A E E A N S P D V T A G C D P A G V H P P R
100200300400500600700SequenceGHITBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q08J23-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q08J23-F1.cif  
DSSP Secondary Structures   Q08J23.dssp  





Publications:

Links:

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