Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA (guanine(37)-N1)-methyltransferase
Synonym: KIAA1393, TRMT5
GI: 145275187
COG: COG2520
UniProt: Q32P41
Alpha Fold Predicted Structure: AF-Q32P41-F1
Enzyme type: methyltransferase
Position of modification - modification: t:37 - m1G
t:37 - o2yW



Protein sequence:

MVLWILWRPFGFSGRFLKLESHSITESKSLIPVAWTSLTQMLLEAPGIFLLGQRKRFSTMPETETHERETELFSPPSDVRGMTKLDRTAFKKTVNIPVLKVRKEIVSKLMRSLKRAALQRPGIRRVIEDPEDKESRLIMLDPYKIFTHDSFEKAELSVLEQLNVSPQISKYNLELTYEHFKSEEILRAVLPEGQDVTSGFSRIGHIAHLNLRDHQLSFKHLIGQVMIDKNPGITSAVNKINNIDNMYRNFQMEVLSGEQNMMTKVRENNYTYEFDFSKVYWNPRLSTEHSRITELLKPGDVLFDVFAGVGPFAIPVAKKNCTVFANDLNPESHKWLLYNCKLNKVDQKVKVFNLDGKDFLQGPVKEELMQLLGLSKERKPSVHVVMNLPAKAIEFLSAFKWLLDGQPCSSEFLPIVHCYSFSKDANPAEDVRQRAGAVLGISLEACSSVHLVRNVAPNKEMLCITFQIPASVLYKNQTRNPENHEDPPLKRQRTAEAFSDEKTQIVSNT

Comments:

The activity was studied using yeast tRNAPhe and E. coli tRNALeu. It was shown to catalyze also I->m1I reaction in position 37 in E.coli tRNAAsp hence it is predicted to participate in the formation of m1I in position 37 of human tRNAAla.





Alpha Fold Predicted Structure:




Parsing response... [471709/471709]


Clear Selection and Reset Camera

Protein sequence:

M V L W I L W R P F G F S G R F L K L E S H S I T E S K S L I P V A W T S L T Q M L L E A P G I F L L G Q R K R F S T M P E T E T H E R E T E L F S P P S D V R G M T K L D R T A F K K T V N I P V L K V R K E I V S K L M R S L K R A A L Q R P G I R R V I E D P E D K E S R L I M L D P Y K I F T H D S F E K A E L S V L E Q L N V S P Q I S K Y N L E L T Y E H F K S E E I L R A V L P E G Q D V T S G F S R I G H I A H L N L R D H Q L S F K H L I G Q V M I D K N P G I T S A V N K I N N I D N M Y R N F Q M E V L S G E Q N M M T K V R E N N Y T Y E F D F S K V Y W N P R L S T E H S R I T E L L K P G D V L F D V F A G V G P F A I P V A K K N C T V F A N D L N P E S H K W L L Y N C K L N K V D Q K V K V F N L D G K D F L Q G P V K E E L M Q L L G L S K E R K P S V H V V M N L P A K A I E F L S A F K W L L D G Q P C S S E F L P I V H C Y S F S K D A N P A E D V R Q R A G A V L G I S L E A C S S V H L V R N V A P N K E M L C I T F Q I P A S V L Y K N Q T R N P E N H E D P P L K R Q R T A E A F S D E K T Q I V S N T
50100150200250300350400450500SequenceGHITBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q32P41-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q32P41-F1.cif  
DSSP Secondary Structures   Q32P41.dssp  





Publications:

Links:

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