TRM5 from Homo sapiens - protein summary.
Position of modification - modification:
t:37 - m1G
t:37 - o2yW
The activity was studied using yeast tRNAPhe and E. coli tRNALeu. It was shown to catalyze also I->m1I reaction in position 37 in E.coli tRNAAsp hence it is predicted to participate in the formation of m1I in position 37 of human tRNAAla.
Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein.
Brule H, Elliott M, Redlak M, Zehner ZE, Holmes WM
Conservation of structure and mechanism by Trm5 enzymes.
Christian T, Gamper H, Hou YM...
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