Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA (guanine-N(7)-)-methyltransferase
Synonym: TRMB
GI: 167004078
Orf: C12orf1
COG: COG0220
UniProt: Q9UBP6
Structures: | 3CKK | 7OGJ | 7PL1 | 8D58 | 8D9K | 8D59 | 8D5B | 8D9L | 8EG0 |
Alpha Fold Predicted Structure: AF-Q9UBP6-F1
Complex: TRMB/WDR4
Enzyme type: methyltransferase
Position of modification - modification: t:46 - m7G


PDB Structures:


3CKK

Structure Description:

Title: Crystal structure of human methyltransferase-like protein 1
Classification: TRANSFERASE
Technique: X-Ray Diffraction
Resolution: 1.55
R value free: 0.218
R value observed: 0.2
R value work: 0.199

Abstract of the PDB Structure's related Publication:

Yet to be published

Download RCSB-PDB Structures:

Pdb Files   3CKK.pdb   7OGJ.pdb   7PL1.pdb   8D58.pdb   8D59.pdb   8D9K.pdb   8D9L.pdb   8EG0.pdb  
Pdbx/mmCIF Files   3CKK.cif   7OGJ.cif   7PL1.cif   8D58.cif   8D59.cif   8D9K.cif   8D9L.cif   8EG0.cif  


Protein sequence:

MAAETRNVAGAEAPPPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELYPEFFAPLTQNQSHDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPAGGFQNIACLRSNAMKHLPNFFYKGQLTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLELHDWMCTHFEEHPLFERVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNFPAIFRRIQDPVLQAVTSQTSLPGH

Comments:

Homolog of yeast Trm8. Requires WDR4 protein for acitivity. The activity was assayed on yeast tRNAPhe. .





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M A A E T R N V A G A E A P P P Q K R Y Y R Q R A H S N P M A D H T L R Y P V K P E E M D W S E L Y P E F F A P L T Q N Q S H D D P K D K K E K R A Q A Q V E F A D I G C G Y G G L L V E L S P L F P D T L I L G L E I R V K V S D Y V Q D R I R A L R A A P A G G F Q N I A C L R S N A M K H L P N F F Y K G Q L T K M F F L F P D P H F K R T K H K W R I I S P T L L A E Y A Y V L R V G G L V Y T I T D V L E L H D W M C T H F E E H P L F E R V P L E D L S E D P V V G H L G T S T E E G K K V L R N G G K N F P A I F R R I Q D P V L Q A V T S Q T S L P G H
20406080100120140160180200220240260SequenceGHTSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9UBP6-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9UBP6-F1.cif  
DSSP Secondary Structures   Q9UBP6.dssp  





Publications:

Links:

_PubMed_