| Full name: |
tRNA (guanine-N(7)-)-methyltransferase |
| Synonym: |
TRMB |
| GI: |
167004078 |
| Orf: |
C12orf1 |
| COG: |
COG0220 |
| UniProt: |
Q9UBP6 |
| Structures: |
|
3CKK |
|
| Complex: |
TRMB/WDR4 |
| Enzyme type: |
methyltransferase |
| Position of modification - modification: |
t:46 - m7G
|
Comments:
Homolog of yeast Trm8. Requires WDR4 protein for acitivity. The activity was assayed on yeast tRNAPhe.
.
Protein sequence:
MAAETRNVAGAEAPPPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELYPEFFAPLTQNQSHDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPD
TLILGLEIRVKVSDYVQDRIRALRAAPAGGFQNIACLRSNAMKHLPNFFYKGQLTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDV
LELHDWMCTHFEEHPLFERVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNFPAIFRRIQDPVLQAVTSQTSLPGH
Enzymatic activities:
| Reaction
| Substrate
| Type
| Position
|
|
G:m7G
|
tRNA (t) |
Phe/#AA/unknown |
46 |
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. |
Alexandrov A, Martzen MR, Phizicky EM |
RNA |
[details]
|
12403464
|
-
|
Links:
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