Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
GI: 16445428
COG: COG2319
UniProt: P57081
Structures: | 8D9K | 8EG0 | 8D9L | 8CTH | 8CTI | 7U20 | 8D59 | 8D5B | 8D58 |
Alpha Fold Predicted Structure: AF-P57081-F1
Complex: TRMB/WDR4


PDB Structures:


8D9K

Structure Description:

Title: Crystal structure of human METTL1 and WDR4 complex
Classification: TRANSFERASE
Technique: X-Ray Diffraction
Resolution: 3.10
R value free: 0.271
R value observed: 0.224
R value work: 0.222

Abstract of the PDB Structure's related Publication:

Yet to be published

Download RCSB-PDB Structures:

Pdb Files   7U20.pdb   8CTH.pdb   8CTI.pdb   8D58.pdb   8D59.pdb   8D9K.pdb   8D9L.pdb   8EG0.pdb  
Pdbx/mmCIF Files   7U20.cif   8CTH.cif   8CTI.cif   8D58.cif   8D59.cif   8D9K.cif   8D9L.cif   8EG0.cif  


Protein sequence:

MAGSVGLALCGQTLVVRGGSRFLATSIASSDDDSLFIYDCSAAEKKSQENKGEDAPLDQGSGAILASTFSKSGSYFALTDDSKRLILFRTKPWQCLSVRTVARRCTALTFIASEEKVLVADKSGDVYSFSVLEPHGCGRLELGHLSMLLDVAVSPDDRFILTADRDEKIRVSWAAAPHSIESFCLGHTEFVSRISVVPTQPGLLLSSSGDGTLRLWEYRSGRQLHCCHLASLQELVDPQAPQKFAASRIAFWCQENCVALLCDGTPVVYIFQLDARRQQLVYRQQLAFQHQVWDVAFEETQGLWVLQDCQEAPLVLYRPVGDQWQSVPESTVLKKVSGVLRGNWAMLEGSAGADASFSSLYKATFDNVTSYLKKKEERLQQQLEKKQRRRSPPPGPDGHAKKMRPGEATLSC

Comments:

Homolog of yeast Trm82. Required for the formation of m7G by TRMB (non-catalytic subunit of the complex).





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M A G S V G L A L C G Q T L V V R G G S R F L A T S I A S S D D D S L F I Y D C S A A E K K S Q E N K G E D A P L D Q G S G A I L A S T F S K S G S Y F A L T D D S K R L I L F R T K P W Q C L S V R T V A R R C T A L T F I A S E E K V L V A D K S G D V Y S F S V L E P H G C G R L E L G H L S M L L D V A V S P D D R F I L T A D R D E K I R V S W A A A P H S I E S F C L G H T E F V S R I S V V P T Q P G L L L S S S G D G T L R L W E Y R S G R Q L H C C H L A S L Q E L V D P Q A P Q K F A A S R I A F W C Q E N C V A L L C D G T P V V Y I F Q L D A R R Q Q L V Y R Q Q L A F Q H Q V W D V A F E E T Q G L W V L Q D C Q E A P L V L Y R P V G D Q W Q S V P E S T V L K K V S G V L R G N W A M L E G S A G A D A S F S S L Y K A T F D N V T S Y L K K K E E R L Q Q Q L E K K Q R R R S P P P G P D G H A K K M R P G E A T L S C
50100150200250300350400SequenceGHTBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-P57081-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-P57081-F1.cif  
DSSP Secondary Structures   P57081.dssp  





Publications:

Links:

_PubMed_