ID Card:
Full name:
tRNA modification GTPase GTPBP3, mitochondrial
Synonym:
MTGP1
GI:
193082991
COG:
COG0486
UniProt:
Q969Y2
Alpha Fold Predicted Structure:
AF-Q969Y2-F1
Enzyme type:
GTPase
Protein sequence:
MWRGLWTLAAQAARGPRRLCTRRSSGAPAPGSGATIFALSSGQGRCGIAVIRTSGPASGHALRILTAPRDLPLARHASLRLLSDPRSGEPLDRALVLWFPGPQSFTGEDCVEFHVHGGPAVVSGVLQALGSVPGLRPAEAGEFTRRAFANGKLNLTEVEGLADLIHAETEAQRRQALRQLDGELGHLCRGWAETLTKALAHVEAYIDFGEDDNLEEGVLEQADIEVRALQVALGAHLRDARRGQRLRSGVHVVVTGPPNAGKSSLVNLLSRKPVSIVSPEPGTTRDVLETPVDLAGFPVLLSDTAGLREGVGPVEQEGVRRARERLEQADLILAMLDASDLASPSSCNFLATVVASVGAQSPSDSSQRLLLVLNKSDLLSPEGPGPGPDLPPHLLLSCLTGEGLDGLLEALRKELAAVCGDPSTDPPLLTRARHQHHLQGCLDALGHYKQSKDLALAAEALRVARGHLTRLTGGGGTEEILDIIFQDFCVGK
Comments:
Homolog of bacterial MnmE and yeast Mss1.
The protein exists in several isoforms. Presented sequence refers to isoform I (also known as V). This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. GTPase involved in the 5-carboxymethylaminomethyl modification (mnm5s2U34) of the wobble uridine base in mitochondrial tRNAs
Alpha Fold Predicted Structure:
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Protein sequence:
M
W
R
G
L
W
T
L
A
A
Q
A
A
R
G
P
R
R
L
C
T
R
R
S
S
G
A
P
A
P
G
S
G
A
T
I
F
A
L
S
S
G
Q
G
R
C
G
I
A
V
I
R
T
S
G
P
A
S
G
H
A
L
R
I
L
T
A
P
R
D
L
P
L
A
R
H
A
S
L
R
L
L
S
D
P
R
S
G
E
P
L
D
R
A
L
V
L
W
F
P
G
P
Q
S
F
T
G
E
D
C
V
E
F
H
V
H
G
G
P
A
V
V
S
G
V
L
Q
A
L
G
S
V
P
G
L
R
P
A
E
A
G
E
F
T
R
R
A
F
A
N
G
K
L
N
L
T
E
V
E
G
L
A
D
L
I
H
A
E
T
E
A
Q
R
R
Q
A
L
R
Q
L
D
G
E
L
G
H
L
C
R
G
W
A
E
T
L
T
K
A
L
A
H
V
E
A
Y
I
D
F
G
E
D
D
N
L
E
E
G
V
L
E
Q
A
D
I
E
V
R
A
L
Q
V
A
L
G
A
H
L
R
D
A
R
R
G
Q
R
L
R
S
G
V
H
V
V
V
T
G
P
P
N
A
G
K
S
S
L
V
N
L
L
S
R
K
P
V
S
I
V
S
P
E
P
G
T
T
R
D
V
L
E
T
P
V
D
L
A
G
F
P
V
L
L
S
D
T
A
G
L
R
E
G
V
G
P
V
E
Q
E
G
V
R
R
A
R
E
R
L
E
Q
A
D
L
I
L
A
M
L
D
A
S
D
L
A
S
P
S
S
C
N
F
L
A
T
V
V
A
S
V
G
A
Q
S
P
S
D
S
S
Q
R
L
L
L
V
L
N
K
S
D
L
L
S
P
E
G
P
G
P
G
P
D
L
P
P
H
L
L
L
S
C
L
T
G
E
G
L
D
G
L
L
E
A
L
R
K
E
L
A
A
V
C
G
D
P
S
T
D
P
P
L
L
T
R
A
R
H
Q
H
H
L
Q
G
C
L
D
A
L
G
H
Y
K
Q
S
K
D
L
A
L
A
A
E
A
L
R
V
A
R
G
H
L
T
R
L
T
G
G
G
G
T
E
E
I
L
D
I
I
F
Q
D
F
C
V
G
K
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
A human mitochondrial GTP binding protein related to tRNA modification may modulate phenotypic expression of the deafness-associated mitochondrial 12S rRNA mutation.
Li X, Guan MX...
Mol Cell Biol
[details]
12370316
-