Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA modification GTPase GTPBP3, mitochondrial
Synonym: MTGP1
GI: 193082991
COG: COG0486
UniProt: Q969Y2
Alpha Fold Predicted Structure: AF-Q969Y2-F1
Enzyme type: GTPase



Protein sequence:

MWRGLWTLAAQAARGPRRLCTRRSSGAPAPGSGATIFALSSGQGRCGIAVIRTSGPASGHALRILTAPRDLPLARHASLRLLSDPRSGEPLDRALVLWFPGPQSFTGEDCVEFHVHGGPAVVSGVLQALGSVPGLRPAEAGEFTRRAFANGKLNLTEVEGLADLIHAETEAQRRQALRQLDGELGHLCRGWAETLTKALAHVEAYIDFGEDDNLEEGVLEQADIEVRALQVALGAHLRDARRGQRLRSGVHVVVTGPPNAGKSSLVNLLSRKPVSIVSPEPGTTRDVLETPVDLAGFPVLLSDTAGLREGVGPVEQEGVRRARERLEQADLILAMLDASDLASPSSCNFLATVVASVGAQSPSDSSQRLLLVLNKSDLLSPEGPGPGPDLPPHLLLSCLTGEGLDGLLEALRKELAAVCGDPSTDPPLLTRARHQHHLQGCLDALGHYKQSKDLALAAEALRVARGHLTRLTGGGGTEEILDIIFQDFCVGK

Comments:

Homolog of bacterial MnmE and yeast Mss1. The protein exists in several isoforms. Presented sequence refers to isoform I (also known as V). This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. GTPase involved in the 5-carboxymethylaminomethyl modification (mnm5s2U34) of the wobble uridine base in mitochondrial tRNAs





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M W R G L W T L A A Q A A R G P R R L C T R R S S G A P A P G S G A T I F A L S S G Q G R C G I A V I R T S G P A S G H A L R I L T A P R D L P L A R H A S L R L L S D P R S G E P L D R A L V L W F P G P Q S F T G E D C V E F H V H G G P A V V S G V L Q A L G S V P G L R P A E A G E F T R R A F A N G K L N L T E V E G L A D L I H A E T E A Q R R Q A L R Q L D G E L G H L C R G W A E T L T K A L A H V E A Y I D F G E D D N L E E G V L E Q A D I E V R A L Q V A L G A H L R D A R R G Q R L R S G V H V V V T G P P N A G K S S L V N L L S R K P V S I V S P E P G T T R D V L E T P V D L A G F P V L L S D T A G L R E G V G P V E Q E G V R R A R E R L E Q A D L I L A M L D A S D L A S P S S C N F L A T V V A S V G A Q S P S D S S Q R L L L V L N K S D L L S P E G P G P G P D L P P H L L L S C L T G E G L D G L L E A L R K E L A A V C G D P S T D P P L L T R A R H Q H H L Q G C L D A L G H Y K Q S K D L A L A A E A L R V A R G H L T R L T G G G G T E E I L D I I F Q D F C V G K
50100150200250300350400450SequenceGHITBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q969Y2-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q969Y2-F1.cif  
DSSP Secondary Structures   Q969Y2.dssp  





Publications: