TcdA from Escherichia coli - protein summary.
tRNA threonylcarbamoyladenosine dehydratase A
Position of modification - modification:
t:37 - ct6A
TcdA is an ATP-dependent dehydratase necessary for the conversion of t6A to ct6A. CsdA and CsdE are additional factors involved in ct6A formation. The detailed catalytic mechanism of TcdA and the supportive roles of CsdA and CsdE in ct6A are not known yet.
A cyclic form of N(6)-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification.
Miyauchi K, Kimura S, Suzuki T...
Nat Chem Biol
The Structure of Escherichia coli TcdA (Also Known As CsdL) Reveals a Novel Topology and Provides Insight into the tRNA Binding Surface Required for N-Threonylcarbamoyladenosine Dehydratase Activity.
Kim S, Lee H, Park S...
J Mol Biol
The crystal structure and small-angle X-ray analysis of CsdL/TcdA reveal a new tRNA binding motif in the MoeB/E1 superfamily.
Lopez-Estepa M, Arda A, Savko M, Round A, Shepard WE, Bruix M, Coll M, Fernandez FJ, Jimenez-Barbero J, Vega MC...
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