ID Card:
Full name:
tRNA methyltransferase 10 C, mitochondrial
Synonym:
MRPP1, RG9MTD1
GI:
117647226
UniProt:
Q7L0Y3
Structures:
|
5NFJ |
7ONU |
Alpha Fold Predicted Structure:
AF-Q7L0Y3-F1
Complex:
mtRNase P
Enzyme type:
methyltransferase
Position of modification - modification:
t :9 - m1G t :9 - m1A
PDB Structures:
5NFJ
7ONU
}
5NFJ
Structure Description:
Abstract of the PDB Structure's related Publication:
Download RCSB-PDB Structures:
Protein sequence:
MAAFLKMSVSVNFFRPFTRFLVPFTLHRKRNNLTILQRYMSSKIPAVTYPKNESTPPSEELELDKWKTTMKSSVQEECVSTISSSKDEDPLAATREFIEMWRLLGREVPEHITEEELKTLMECVSNTAKKKYLKYLYTKEKVKKARQIKKEMKAAAREEAKNIKLLETTEEDKQKNFLFLRLWDRNMDIAMGWKGAQAMQFGQPLVFDMAYENYMKRKELQNTVSQLLESEGWNRRNVDPFHIYFCNLKIDGALHRELVKRYQEKWDKLLLTSTEKSHVDLFPKDSIIYLTADSPNVMTTFRHDKVYVIGSFVDKSMQPGTSLAKAKRLNLATECLPLDKYLQWEIGNKNLTLDQMIRILLCLKNNGNWQEALQFVPKRKHTGFLEISQHSQEFINRLKKAKT
Comments:
Part of mitochondrial RNase P which consists of three proteins: MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391. All three are required for the enzyme endonuclease activity while two (MRPP1/TRMT10C, MRPP2/HSD17B10) are sufficient for methyltransferase activity. MRPP1/TRMT10C is a homolog of yeast Trm10 but unlike the yeast enzyme TRMT10C requires another protein, MRPP2/HSD17B10, to be active as a methyltransferase. Both precursors and mature tRNAs are substrates for the methyltransferase complex.
Reaction
Substrate
SubstrateType
Position
(Anti)Codon
Modified (Anti)Codon
Amino Acid Change
Transcript Name
Transcript Region
Cellular Localization
References
G:m1G
RNA
tRNA
9
GAU
GAU
tRNAIle GAU
~
Mitochondrion
23042678
A:m1A
RNA
tRNA
9
∀UU
∀UU
tRNALys ∀UU
~
Mitochondrion
23042678
Alpha Fold Predicted Structure:
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Protein sequence:
M
A
A
F
L
K
M
S
V
S
V
N
F
F
R
P
F
T
R
F
L
V
P
F
T
L
H
R
K
R
N
N
L
T
I
L
Q
R
Y
M
S
S
K
I
P
A
V
T
Y
P
K
N
E
S
T
P
P
S
E
E
L
E
L
D
K
W
K
T
T
M
K
S
S
V
Q
E
E
C
V
S
T
I
S
S
S
K
D
E
D
P
L
A
A
T
R
E
F
I
E
M
W
R
L
L
G
R
E
V
P
E
H
I
T
E
E
E
L
K
T
L
M
E
C
V
S
N
T
A
K
K
K
Y
L
K
Y
L
Y
T
K
E
K
V
K
K
A
R
Q
I
K
K
E
M
K
A
A
A
R
E
E
A
K
N
I
K
L
L
E
T
T
E
E
D
K
Q
K
N
F
L
F
L
R
L
W
D
R
N
M
D
I
A
M
G
W
K
G
A
Q
A
M
Q
F
G
Q
P
L
V
F
D
M
A
Y
E
N
Y
M
K
R
K
E
L
Q
N
T
V
S
Q
L
L
E
S
E
G
W
N
R
R
N
V
D
P
F
H
I
Y
F
C
N
L
K
I
D
G
A
L
H
R
E
L
V
K
R
Y
Q
E
K
W
D
K
L
L
L
T
S
T
E
K
S
H
V
D
L
F
P
K
D
S
I
I
Y
L
T
A
D
S
P
N
V
M
T
T
F
R
H
D
K
V
Y
V
I
G
S
F
V
D
K
S
M
Q
P
G
T
S
L
A
K
A
K
R
L
N
L
A
T
E
C
L
P
L
D
K
Y
L
Q
W
E
I
G
N
K
N
L
T
L
D
Q
M
I
R
I
L
L
C
L
K
N
N
G
N
W
Q
E
A
L
Q
F
V
P
K
R
K
H
T
G
F
L
E
I
S
Q
H
S
Q
E
F
I
N
R
L
K
K
A
K
T
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis.
Vilardo E, Nachbagauer C, Buzet A, Taschner A, Holzmann J, Rossmanith W...
Nucleic Acids Res
[details]
23042678
-
Links: