| Full name: |
tRNA methyltransferase 10 C, mitochondrial |
| Synonym: |
MRPP1, RG9MTD1 |
| GI: |
117647226 |
| Orf: |
|
| COG: |
|
| UniProt: |
Q7L0Y3 |
| Structures: |
|
|
|
| Complex: |
mtRNase P |
| Enzyme type: |
methyltransferase |
| Position of modification - modification: |
t:9 - m1G
t:9 - m1A
|
Comments:
Part of mitochondrial RNase P which consists of three proteins: MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391. All three are required for the enzyme endonuclease activity while two (MRPP1/TRMT10C, MRPP2/HSD17B10) are sufficient for methyltransferase activity. MRPP1/TRMT10C is a homolog of yeast Trm10 but unlike the yeast enzyme TRMT10C requires another protein, MRPP2/HSD17B10, to be active as a methyltransferase. Both precursors and mature tRNAs are substrates for the methyltransferase complex.
Protein sequence:
MAAFLKMSVSVNFFRPFTRFLVPFTLHRKRNNLTILQRYMSSKIPAVTYPKNESTPPSEELELDKWKTTMKSSVQEECVSTISSSKDEDPLAATREFIEM
WRLLGREVPEHITEEELKTLMECVSNTAKKKYLKYLYTKEKVKKARQIKKEMKAAAREEAKNIKLLETTEEDKQKNFLFLRLWDRNMDIAMGWKGAQAMQ
FGQPLVFDMAYENYMKRKELQNTVSQLLESEGWNRRNVDPFHIYFCNLKIDGALHRELVKRYQEKWDKLLLTSTEKSHVDLFPKDSIIYLTADSPNVMTT
FRHDKVYVIGSFVDKSMQPGTSLAKAKRLNLATECLPLDKYLQWEIGNKNLTLDQMIRILLCLKNNGNWQEALQFVPKRKHTGFLEISQHSQEFINRLKK
AKT
Enzymatic activities:
| Reaction
| Substrate
| Type
| Position
|
|
G:m1G
|
tRNA (t) |
Ile/GAU/prokaryotic cytosol |
9 |
|
A:m1A
|
tRNA (t) |
Lys/∀UU/mitochondrion |
9 |
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. |
Vilardo E, Nachbagauer C, Buzet A, Taschner A, Holzmann J, Rossmanith W... |
Nucleic Acids Res |
[details]
|
23042678
|
-
|
Links:
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