Modomics - A Database of RNA Modifications

Full name:	Ribosomal RNA large subunit methyltransferase O
Synonym:	TTHA1493
GI:	55981462
Orf:
COG:	COG1092
UniProt:	Q5SI81
Structures:	\| 4DMG \|
Complex:
Enzyme type:	methyltransferase
Position of modification - modification:	l:1964(1942) - m5C

Comments:

RlmO modifies naked 23 S rRNA, but not the assembled 50 S subunit or 70 S ribosomes.

Protein sequence:

MLGPVLRLVVKAGKERKLRNFYPNLYRDEIAAPPEGVGVAEAVDAEGHFLAVGYYDPRSRVPFRAFRFDPGPLNRAFFQGRFARALRRRQGLGESHRLVH
GEADGLPGLVVDRFGEVLVLQVRSRGMEALREVWLPALLEVVAPKGVYERSDVEARRQEGLPERVGVVYGEVPEVLEVEEDGLRFPIPLALAQKTGYYLD
QRENRRLFEAMVRPGERVLDVYSYVGGFALRAARKGAYALAVDKDLEALGVLDQAALRLGLRVDIRHGEALPTLRGLEGPFHHVLLDPPTLVKRPEELPA
MKRHLVDLVREALRLLAEEGFLWLSSCSYHLRLEDLLEVARRAAADLGRRLRVHRVTYQPEDHPWSLHIPESLYLKTLVLQDDPL

Enzymatic activities:

Reaction	Substrate	Type	Position
C:m5C	rRNA (r)	LSU/23S/prokaryotic cytosol	1964

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Identification and characterization of the Thermus thermophilus 5-methylcytidine (m5C) methyltransferase modifying 23 S ribosomal RNA (rRNA) base C1942.	Larsen LH, Rasmussen A, Giessing AM, Jogl G, Kirpekar F...	J Biol Chem	[details]	22711535	-

Links:

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