Full name:
Synonym: YBR141C
GI: 330443457
Orf: YBR1118
COG:
UniProt: P38278
Structures: | |
Complex:
Enzyme type: methyltransferase
Position of modification - modification: l:2142(1784) - m1A

Comments:

Intriduces m1A2142 modification of helix 65 in domain IV of 25S rRNA. Predicted to be an Ado-Met dependent methyltransferase from Rossmann fold superfamily. The loss of m1A2142 modification confers anisomycin and peroxide sensitivity to the cells.

Protein sequence:

MHSRKSKSITGKRKQVGSNVTRVIKPQKTRRIIRRFHHLINKRQSICKFLCLKENLDDSNEEKNDKIIRL SIKGNVRLGKYYEDGKSQSFNDAMESQLLRLHSLIKNESKSKDTSDLAVMYTLLGYIMNQINKLGGLETY QIASQNGQLKERGGDTSKLLEKWIRSSFENCPGAVALEIGSLSSGNRISRCALFRNVVRIDLEEHEGVIK QDFMERPLPRNENDKFDLISCSLVLNFVKNHRDRGAMCHRMVKFLKPQGYIFIVLPQACVTHSRYCDKTL LQNLLGSIGLIMLNSHQSNKLYYCLYQLQVVPPQPSSFSKRIKVNDGPGLNNFGITL

Enzymatic activities:

Reaction Substrate Type Position
A:m1A rRNA (r) LSU-L/25S/cytosolic 2142

Publications:

Title Authors Journal Details PubMed Id DOI
Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae Sunny Sharma, Peter Watzinger, Peter Kötter, and Karl-Dieter Entian Nucleic Acids Res [details] 23558746 10.1093/nar/gkt195
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