Full name: tRNA (guanosine(18)-2′-O)-methyltransferase
Synonym: SpoU
GI: 55980096
Orf: TTHA0127
COG: COG0566
UniProt: Q9FAC4
Structures: | 1V2X |
Complex:
Enzyme type: methyltransferase
Position of modification - modification: t:18 - Gm

Comments:

T. thermophilus TrmH is a Class IV AdoMet-dependent methyltransferase.

Protein sequence:

MRERTEARRRRIEEVLRRRQPDLTVLLENVHKPHNLSAILRTCDAVGVLEAHAVNPTGGVPTFNETSGGS HKWVYLRVHPDLHEAFRFLKERGFTVYATALREDARDFREVDYTKPTAVLFGAEKWGVSEEALALADGAI KIPMLGMVQSLNVSVAAAVILFEAQRQRLKAGLYDRPRLDPELYQKVLADWLRK

Enzymatic activities:

Reaction Substrate Type Position
G:Gm tRNA (t) all/all/cytosolic 18

Publications:

Title Authors Journal Details PubMed Id DOI
Identification and characterization of tRNA (Gm18) methyltransferase from Thermus thermophilus HB8: domain structure and conserved amino acid sequence motifs. Hori H, Suzuki T, Sugawara K, Inoue Y, Shibata T, Kuramitsu S, Yokoyama S, Oshima T, Watanabe K... Genes Cells [details] 11918670 -
Substrate recognition of tRNA (Guanosine-2'-)-methyltransferase from Thermus thermophilus HB27. Hori H, Yamazaki N, Matsumoto T, Watanabe Y, Ueda T, Nishikawa K, Kumagai I, Watanabe K... J Biol Chem [details] 9748240 -
Deep knot structure for construction of active site and cofactor binding site of tRNA modification enzyme. Nureki O, Watanabe K, Fukai S, Ishii R, Endo Y, Hori H, Yokoyama S... Structure [details] 15062082 -
The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and non-substrate tRNA via an induced-fit process. Ochi A, Makabe K, Yamagami R, Hirata A, Sakaguchi R, Hou YM, Watanabe K, Nureki O, Kuwajima K, Hori H... J Biol Chem [details] 23867454 -

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