Modomics - A Database of RNA Modifications

ID Card:

Full name: Ribosomal RNA Cytosine Methyltransferase 1
Synonym: Ynl022c
GI: 398365407
Orf: N2815
COG: COG0144
UniProt: P53972
Alpha Fold Predicted Structure: AF-P53972-F1
Enzyme type: methyltransferase
Position of modification - modification: l:2278(1935) - m5C



Protein sequence:

MNFYRDATWVLEDIEKEAAKERISGSMQTLVLKSCKRYKLKSNPKHIYAVLDSCWKYKPYLEKVMKKAHILEDIPKKKGKPLFSRLTLLLLCHDLLLSKQKRIQMGKHPIKDYVLKFKSPLHSEMVKLKLKLKVRELSELVLSEDISNDLPPVRWIRINPLKCHPNGETEPVLAELRKKFTLKVDKWSELVPGSIYYDEFIPNLFGIHPSDKITAHELYKHGKIIIQDRASCFPAHILNPGPSDIVIDSCSAPGNKTTHTASYIYPEPPKDNNTRIYAFEKDPERAKVLQKMIKIAGCSPNISVNVGDFTKLATPEKYKDVTCFIVDPSCSGSGIFGRKFFDSFNRRKIDDKDDDGGIVPDEQEEFIAKEELQTRLAKLSSFQFQMVKHAMSFPAAKKIVYSTCSIHAEENERVVIDLLLDKSVREWGWKVAPKREVIPSWPRRGKVEEFEEVFRDGVTYDPQQLAEGCIRALPKSDGGIGFFAVCFERD

Comments:

The loss of m5C2278 results in anisomycin hypersensitivity. A combined loss of m5C2278 and Gm2288 cause dramatic ribosome instability, resulting in loss of 60S ribosomal subunits. Rcm1 interacts with Trm112 but deletion of Trm112 has no significant effect on the modification state of cytosine 2278.





Alpha Fold Predicted Structure:




Parsing response... [456091/456091]


Clear Selection and Reset Camera

Protein sequence:

M N F Y R D A T W V L E D I E K E A A K E R I S G S M Q T L V L K S C K R Y K L K S N P K H I Y A V L D S C W K Y K P Y L E K V M K K A H I L E D I P K K K G K P L F S R L T L L L L C H D L L L S K Q K R I Q M G K H P I K D Y V L K F K S P L H S E M V K L K L K L K V R E L S E L V L S E D I S N D L P P V R W I R I N P L K C H P N G E T E P V L A E L R K K F T L K V D K W S E L V P G S I Y Y D E F I P N L F G I H P S D K I T A H E L Y K H G K I I I Q D R A S C F P A H I L N P G P S D I V I D S C S A P G N K T T H T A S Y I Y P E P P K D N N T R I Y A F E K D P E R A K V L Q K M I K I A G C S P N I S V N V G D F T K L A T P E K Y K D V T C F I V D P S C S G S G I F G R K F F D S F N R R K I D D K D D D G G I V P D E Q E E F I A K E E L Q T R L A K L S S F Q F Q M V K H A M S F P A A K K I V Y S T C S I H A E E N E R V V I D L L L D K S V R E W G W K V A P K R E V I P S W P R R G K V E E F E E V F R D G V T Y D P Q Q L A E G C I R A L P K S D G G I G F F A V C F E R D
50100150200250300350400450SequenceGHTBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-P53972-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-P53972-F1.cif  
DSSP Secondary Structures   P53972.dssp  





Publications:

Links:

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