ID Card:
Full name:
tRNA wybutosine-synthesizing protein 2
Synonym:
TRMT12
GI:
74726289
COG:
COG2520
UniProt:
Q53H54
Alpha Fold Predicted Structure:
AF-Q53H54-F1
Enzyme type:
Alpha-amino-alpha-carboxypropyltransferase
Position of modification - modification:
t :37 - o2yW
Protein sequence:
MRENVVVSNMERESGKPVAVVAVVTEPWFTQRYREYLQRQKLFDTQHRVEKMPDGSVALPVLGETLPEQHLQELRNRVAPGSPCMLTQLPDPVPSKRAQGCSPAQKLCLEVSRWVEGRGVKWSAELEADLPRSWQRHGNLLLLSEDCFQAKQWKNLGPELWETVALALGVQRLAKRGRVSPDGTRTPAVTLLLGDHGWVEHVDNGIRYKFDVTQCMFSFGNITEKLRVASLSCAGEVLVDLYAGIGYFTLPFLVHAGAAFVHACEWNPHAVVALRNNLEINGVADRCQIHFGDNRKLKLSNIADRVILGLIPSSEEGWPIACQVLRQDAGGILHIHQNVESFPGKNLQALGVSKVEKEHWLYPQQITTNQWKNGATRDSRGKMLSPATKPEWQRWAESAETRIATLLQQVHGKPWKTQILHIQPVKSYAPHVDHIVLDLECCPCPSVG
Comments:
It was demonstrated that human TYW2 (hTYW2) is active in yeast and can synthesize the yW of yeast tRNAPhe. Human TYW2 (hTYW2) was found to be amplified and overexpressed in breast cancer.
Alpha Fold Predicted Structure:
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Protein sequence:
M
R
E
N
V
V
V
S
N
M
E
R
E
S
G
K
P
V
A
V
V
A
V
V
T
E
P
W
F
T
Q
R
Y
R
E
Y
L
Q
R
Q
K
L
F
D
T
Q
H
R
V
E
K
M
P
D
G
S
V
A
L
P
V
L
G
E
T
L
P
E
Q
H
L
Q
E
L
R
N
R
V
A
P
G
S
P
C
M
L
T
Q
L
P
D
P
V
P
S
K
R
A
Q
G
C
S
P
A
Q
K
L
C
L
E
V
S
R
W
V
E
G
R
G
V
K
W
S
A
E
L
E
A
D
L
P
R
S
W
Q
R
H
G
N
L
L
L
L
S
E
D
C
F
Q
A
K
Q
W
K
N
L
G
P
E
L
W
E
T
V
A
L
A
L
G
V
Q
R
L
A
K
R
G
R
V
S
P
D
G
T
R
T
P
A
V
T
L
L
L
G
D
H
G
W
V
E
H
V
D
N
G
I
R
Y
K
F
D
V
T
Q
C
M
F
S
F
G
N
I
T
E
K
L
R
V
A
S
L
S
C
A
G
E
V
L
V
D
L
Y
A
G
I
G
Y
F
T
L
P
F
L
V
H
A
G
A
A
F
V
H
A
C
E
W
N
P
H
A
V
V
A
L
R
N
N
L
E
I
N
G
V
A
D
R
C
Q
I
H
F
G
D
N
R
K
L
K
L
S
N
I
A
D
R
V
I
L
G
L
I
P
S
S
E
E
G
W
P
I
A
C
Q
V
L
R
Q
D
A
G
G
I
L
H
I
H
Q
N
V
E
S
F
P
G
K
N
L
Q
A
L
G
V
S
K
V
E
K
E
H
W
L
Y
P
Q
Q
I
T
T
N
Q
W
K
N
G
A
T
R
D
S
R
G
K
M
L
S
P
A
T
K
P
E
W
Q
R
W
A
E
S
A
E
T
R
I
A
T
L
L
Q
Q
V
H
G
K
P
W
K
T
Q
I
L
H
I
Q
P
V
K
S
Y
A
P
H
V
D
H
I
V
L
D
L
E
C
C
P
C
P
S
V
G
50 100 150 200 250 300 350 400 Sequence G H I T B S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
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