Full name: tRNA wybutosine-synthesizing protein 2
Synonym: TRMT12
GI: 74726289
Orf:
COG: COG2520
UniProt: Q53H54
Structures: | |
Complex:
Enzyme type: Alpha-amino-alpha-carboxypropyltransferase
Position of modification - modification: t:37 - o2yW

Comments:

It was demonstrated that human TYW2 (hTYW2) is active in yeast and can synthesize the yW of yeast tRNAPhe. Human TYW2 (hTYW2) was found to be amplified and overexpressed in breast cancer.

Protein sequence:

MRENVVVSNMERESGKPVAVVAVVTEPWFTQRYREYLQRQKLFDTQHRVEKMPDGSVALPVLGETLPEQH LQELRNRVAPGSPCMLTQLPDPVPSKRAQGCSPAQKLCLEVSRWVEGRGVKWSAELEADLPRSWQRHGNL LLLSEDCFQAKQWKNLGPELWETVALALGVQRLAKRGRVSPDGTRTPAVTLLLGDHGWVEHVDNGIRYKF DVTQCMFSFGNITEKLRVASLSCAGEVLVDLYAGIGYFTLPFLVHAGAAFVHACEWNPHAVVALRNNLEI NGVADRCQIHFGDNRKLKLSNIADRVILGLIPSSEEGWPIACQVLRQDAGGILHIHQNVESFPGKNLQAL GVSKVEKEHWLYPQQITTNQWKNGATRDSRGKMLSPATKPEWQRWAESAETRIATLLQQVHGKPWKTQIL HIQPVKSYAPHVDHIVLDLECCPCPSVG

Publications:

Title Authors Journal Details PubMed Id DOI
Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA. Rodriguez V, Vasudevan S, Noma A, Carlson BA, Green JE, Suzuki T, Chandrasekharappa SC PLoS One [details] 22761755 -
Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer. Rodriguez V, Chen Y, Elkahloun A, Dutra A, Pak E, Chandrasekharappa S Genes Chromosomes Cancer [details] 17440925 -

Links:

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