ID Card:
Full name:
tRNA wybutosine-synthesizing protein 2
Synonym:
TRMT12
GI:
74726289
COG:
COG2520
UniProt:
Q53H54
Alpha Fold Predicted Structure:
AF-Q53H54-F1
Enzyme type:
Alpha-amino-alpha-carboxypropyltransferase
Position of modification - modification:
t :37 - o2yW
Protein sequence:
MRENVVVSNMERESGKPVAVVAVVTEPWFTQRYREYLQRQKLFDTQHRVEKMPDGSVALPVLGETLPEQHLQELRNRVAPGSPCMLTQLPDPVPSKRAQGCSPAQKLCLEVSRWVEGRGVKWSAELEADLPRSWQRHGNLLLLSEDCFQAKQWKNLGPELWETVALALGVQRLAKRGRVSPDGTRTPAVTLLLGDHGWVEHVDNGIRYKFDVTQCMFSFGNITEKLRVASLSCAGEVLVDLYAGIGYFTLPFLVHAGAAFVHACEWNPHAVVALRNNLEINGVADRCQIHFGDNRKLKLSNIADRVILGLIPSSEEGWPIACQVLRQDAGGILHIHQNVESFPGKNLQALGVSKVEKEHWLYPQQITTNQWKNGATRDSRGKMLSPATKPEWQRWAESAETRIATLLQQVHGKPWKTQILHIQPVKSYAPHVDHIVLDLECCPCPSVG
Comments:
It was demonstrated that human TYW2 (hTYW2) is active in yeast and can synthesize the yW of yeast tRNAPhe. Human TYW2 (hTYW2) was found to be amplified and overexpressed in breast cancer.
Alpha Fold Predicted Structure:
Clear Selection and Reset Camera
Clear Selection
Reset Camera
Protein sequence:
M
R
E
N
V
V
V
S
N
M
E
R
E
S
G
K
P
V
A
V
V
A
V
V
T
E
P
W
F
T
Q
R
Y
R
E
Y
L
Q
R
Q
K
L
F
D
T
Q
H
R
V
E
K
M
P
D
G
S
V
A
L
P
V
L
G
E
T
L
P
E
Q
H
L
Q
E
L
R
N
R
V
A
P
G
S
P
C
M
L
T
Q
L
P
D
P
V
P
S
K
R
A
Q
G
C
S
P
A
Q
K
L
C
L
E
V
S
R
W
V
E
G
R
G
V
K
W
S
A
E
L
E
A
D
L
P
R
S
W
Q
R
H
G
N
L
L
L
L
S
E
D
C
F
Q
A
K
Q
W
K
N
L
G
P
E
L
W
E
T
V
A
L
A
L
G
V
Q
R
L
A
K
R
G
R
V
S
P
D
G
T
R
T
P
A
V
T
L
L
L
G
D
H
G
W
V
E
H
V
D
N
G
I
R
Y
K
F
D
V
T
Q
C
M
F
S
F
G
N
I
T
E
K
L
R
V
A
S
L
S
C
A
G
E
V
L
V
D
L
Y
A
G
I
G
Y
F
T
L
P
F
L
V
H
A
G
A
A
F
V
H
A
C
E
W
N
P
H
A
V
V
A
L
R
N
N
L
E
I
N
G
V
A
D
R
C
Q
I
H
F
G
D
N
R
K
L
K
L
S
N
I
A
D
R
V
I
L
G
L
I
P
S
S
E
E
G
W
P
I
A
C
Q
V
L
R
Q
D
A
G
G
I
L
H
I
H
Q
N
V
E
S
F
P
G
K
N
L
Q
A
L
G
V
S
K
V
E
K
E
H
W
L
Y
P
Q
Q
I
T
T
N
Q
W
K
N
G
A
T
R
D
S
R
G
K
M
L
S
P
A
T
K
P
E
W
Q
R
W
A
E
S
A
E
T
R
I
A
T
L
L
Q
Q
V
H
G
K
P
W
K
T
Q
I
L
H
I
Q
P
V
K
S
Y
A
P
H
V
D
H
I
V
L
D
L
E
C
C
P
C
P
S
V
G
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA.
Rodriguez V, Vasudevan S, Noma A, Carlson BA, Green JE, Suzuki T, Chandrasekharappa SC
PLoS One
[details]
22761755
-
Links: