ID Card:
Full name:
25S rRNA (uridine(2843)-N(3))-methyltransferase
Synonym:
YLR063W
GI:
6323092
Orf:
L2174
UniProt:
Q12291
Alpha Fold Predicted Structure:
AF-Q12291-F1
Enzyme type:
methyltransferase
Position of modification - modification:
l :2843(2474) - m3U
Protein sequence:
MLLMRRFAFLTSSVYFKYIPIYSQYHYSSQFPINMNPKKVAQLPVHNKSTLPPQEIIDLFKITFLEELYPKDQDNEKSPLTEQIQAVKSDLYNRDYNAAFNNDSKRIAYCCRWSPSRATSYASVFAHFPELLKIIRCEIDDKDSNVLCIGGGAGGELVALASIFTLSRDFSSKFASALKIDNEVNKKPRNLNIQLVDIADWSTVVEKLTATIKSKWLYGDSEAESFNVNFTHKDCLQMTEPQDIKIYQGLDLITLLFTTNELFTQKKVESIKFLQRLNENCAPGCHLLILESAGSYSHITINNKKFPIQFLIDTILVGNRKDKGTTGPWSLVSENDSIWYRMDPKLDYSIPLENMRFFYRLYVKN
Comments:
Btm6 belongs to the Rossmann-fold-like methyltransferases. Point mutations in the S-adenosyl-L-methionine binding pocket abolish the methylation reaction. Bmt5 localizes predominantly in the cytoplasm. Bmt6 methylates the N3 position of uridine 2843 (m3U2843) in the 25s rRNA (Sharma et al. 2014 )
Alpha Fold Predicted Structure:
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Protein sequence:
M
L
L
M
R
R
F
A
F
L
T
S
S
V
Y
F
K
Y
I
P
I
Y
S
Q
Y
H
Y
S
S
Q
F
P
I
N
M
N
P
K
K
V
A
Q
L
P
V
H
N
K
S
T
L
P
P
Q
E
I
I
D
L
F
K
I
T
F
L
E
E
L
Y
P
K
D
Q
D
N
E
K
S
P
L
T
E
Q
I
Q
A
V
K
S
D
L
Y
N
R
D
Y
N
A
A
F
N
N
D
S
K
R
I
A
Y
C
C
R
W
S
P
S
R
A
T
S
Y
A
S
V
F
A
H
F
P
E
L
L
K
I
I
R
C
E
I
D
D
K
D
S
N
V
L
C
I
G
G
G
A
G
G
E
L
V
A
L
A
S
I
F
T
L
S
R
D
F
S
S
K
F
A
S
A
L
K
I
D
N
E
V
N
K
K
P
R
N
L
N
I
Q
L
V
D
I
A
D
W
S
T
V
V
E
K
L
T
A
T
I
K
S
K
W
L
Y
G
D
S
E
A
E
S
F
N
V
N
F
T
H
K
D
C
L
Q
M
T
E
P
Q
D
I
K
I
Y
Q
G
L
D
L
I
T
L
L
F
T
T
N
E
L
F
T
Q
K
K
V
E
S
I
K
F
L
Q
R
L
N
E
N
C
A
P
G
C
H
L
L
I
L
E
S
A
G
S
Y
S
H
I
T
I
N
N
K
K
F
P
I
Q
F
L
I
D
T
I
L
V
G
N
R
K
D
K
G
T
T
G
P
W
S
L
V
S
E
N
D
S
I
W
Y
R
M
D
P
K
L
D
Y
S
I
P
L
E
N
M
R
F
F
Y
R
L
Y
V
K
N
50 100 150 200 250 300 350 Sequence G H T S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications: