Taw22 from Pyrococcus abyssi - protein summary.
tRNA (guanine(37)-N1)-methyltransferase Trm5a/Taw22
Position of modification - modification:
t:37 - mimG
In P. abyssi two paralogs capable of forming m1G37 are present: Trm5b and Taw22 (Trm5a, a bifunctional enzyme). Under identical experimental conditions Taw22 is more selective for G37-containing tRNAPhe.
Taw22 is a tRNA:m1G/imG2 methyltransferase, acting on two chemically distinct guanosine derivatives located at the same position of tRNAPhe, unique to certain archaea. It does not have homologs in eukaryotes.
Biosynthesis of wyosine derivatives in tRNA: an ancient and highly diverse pathway in Archaea.
de Crecy-Lagard V, Brochier-Armanet C, Urbonavicius J, Fernandez B, Phillips G, Lyons B, Noma A, Alvarez S, Droogmans L, Armengaud J, Grosjean H
Mol Biol Evol
Biosynthesis of wyosine derivatives in tRNA(Phe) of Archaea: role of a remarkable bifunctional tRNA(Phe):m1G/imG2 methyltransferase.
Urbonavicius J, Meskys R, Grosjean H...
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