Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA (cytosine(49)-C(5))-methyltransferase
Synonym: PYRAB06230
GI: 14520840
Orf: PAB1947
COG: COG0144
UniProt: Q9V106
Alpha Fold Predicted Structure: AF-Q9V106-F1
Enzyme type: methyltransferase
Position of modification - modification: t:49 - m5C



Protein sequence:

MKRWEHYEHTADIGIRGYGDSLEEAFEAVAIALFDVIVNVNKVEKKEVREVEVEGEDLESLLYNFLEELLVIHDIEGLVFRDFEVKIEKTEKGYKLKAKAYGEKLDPEKHEPKEEVKAITYHDMKIEKLPDGRWMAQLVPDI

Comments:

Catalyzes m5C formation at several cytosines within tRNAs, with preference for C49. The specificity of the enzyme is increased by complex formation with protein archease (PAB1946) encoded upstream from the MTase gene (PAB1947).





Alpha Fold Predicted Structure:




Parsing response... [294911/294911]


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Protein sequence:

M K R W E H Y E H T A D I G I R G Y G D S L E E A F E A V A I A L F D V I V N V N K V E K K E V R E V E V E G E D L E S L L Y N F L E E L L V I H D I E G L V F R D F E V K I E K T E K G Y K L K A K A Y G E K L D P E K H E P K E E V K A I T Y H D M K I E K L P D G R W M A Q L V P D I
20406080100120140MKRWEHYEHTADIGIRGYGDSLEEAFEAVAIALFDVIVNVNKVEKKEVREVEVEGEDLESLLYNFLEELLVIHDIEGLVFRDFEVKIEKTEKGYKLKAKAYGEKLDPEKHEPKEEVKAITYHDMKIEKLPDGRWMAQLVPDISequenceGHTBSN

Enter the variants

Position

Original

Variant

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9V106-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9V106-F1.cif  
DSSP Secondary Structures   Q9V106.dssp  





Publications:

Links:

_PubMed_