| Full name: |
tRNA (cytosine(49)-C(5))-methyltransferase |
| Synonym: |
PYRAB06230 |
| GI: |
14520840 |
| Orf: |
PAB1947 |
| COG: |
COG0144 |
| UniProt: |
Q9V106 |
| Structures: |
|
|
|
| Complex: |
|
| Enzyme type: |
methyltransferase |
| Position of modification - modification: |
t:49 - m5C
|
Comments:
Catalyzes m5C formation at several cytosines within tRNAs, with preference for C49. The specificity of the enzyme is increased by complex formation with protein archease (PAB1946) encoded upstream from the MTase gene (PAB1947).
Protein sequence:
MKRWEHYEHTADIGIRGYGDSLEEAFEAVAIALFDVIVNVNKVEKKEVREVEVEGEDLESLLYNFLEELLVIHDIEGLVFRDFEVKIEKTEKGYKLKAKA
YGEKLDPEKHEPKEEVKAITYHDMKIEKLPDGRWMAQLVPDI
Enzymatic activities:
| Reaction
| Substrate
| Type
| Position
|
|
C:m5C
|
tRNA (t) |
|
49 |
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Archease from Pyrococcus abyssi improves substrate specificity and solubility of a tRNA m5C methyltransferase. |
Auxilien S, El Khadali F, Rasmussen A, Douthwaite S, Grosjean H... |
J Biol Chem |
[details]
|
17470432
|
-
|
Links:
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