ID Card:
Full name:
glutamine:preQ0-tRNA amidinotransferase or Archaeosine Synthase
Synonym:
Archaeosine synthase, Glutamine:preQ0-tRNA amidinotransferase
GI:
3024970
COG:
COG1549
UniProt:
Q58428
Alpha Fold Predicted Structure:
AF-Q58428-F1
Enzyme type:
amidinotransferase
Position of modification - modification:
t :15 - G+
Protein sequence:
MLEPIAYDIGRLCKEEDKELTPKLIDIDVIGLSQEKIFYGIMTPFRCPNSKSIYELRKSYVKADGIKMPFDTFRELTSIFKKSFIGTVKYKGNVFKYQILNFGKHVDLIELEDADLYIIADGRRLIERKELQIIPKIREKISPNSAIYSPAVFPWEIPLLAYIGVDYFDDSLAKLYASMGYKFTKNRAVKVDSFSFEELYNNNKKVYEEILEEVRIAIKNGFLRNVVEETAVSHPYLWANYRRYEPDLRNIPLSKENKIIVTTNINIPEVKKYLERLDNYEPYSNIIVLLPCSSKKPYSISQSHQKFIKAIKSAKVVVEEVILTSPYGLVPRALERLVNYDIPVTGEWSFEEIELINNCLKNFLKKVKEKFDDYIVIAHLPEHYLEILELDDIVITSKGNPTSEEALKNLTDTLKKYKELTKSKDINKKGQRIHNIQQLAEFQFGINFIPNEIFINHKGQIFTKINNKNQQIASINPKNGLLILTLSGGELLWNSGGKDINYIEVNYEIKKGSLFPPGFVDCNENISYNDEVVLIKDDTFLGIGRALMSGFEMKKAKHGALVNIRNVKS
Comments:
7-deazaguanosine derivative archaeosine (G(+) ) at tRNA position 15 is a molecular signature of Archaea. Noteworthy, the biosynthesis of this modified ribonucleotide is complex, involving the initial production of 7-cyano-7-deazaguanine (preQ(0) ). ArcTGTs are an enzyme family responsible for the biosynthesis of pre Q(0). The corresponding gene has been cloned also for Methano caldococcus jannaschii (Philips et al. 2010 ). It was shown to convert pre Q(0) to G(+)-tRNA using several nitrogen sources and to do so in an ATP dependent process.
Alpha Fold Predicted Structure:
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Protein sequence:
M
L
E
P
I
A
Y
D
I
G
R
L
C
K
E
E
D
K
E
L
T
P
K
L
I
D
I
D
V
I
G
L
S
Q
E
K
I
F
Y
G
I
M
T
P
F
R
C
P
N
S
K
S
I
Y
E
L
R
K
S
Y
V
K
A
D
G
I
K
M
P
F
D
T
F
R
E
L
T
S
I
F
K
K
S
F
I
G
T
V
K
Y
K
G
N
V
F
K
Y
Q
I
L
N
F
G
K
H
V
D
L
I
E
L
E
D
A
D
L
Y
I
I
A
D
G
R
R
L
I
E
R
K
E
L
Q
I
I
P
K
I
R
E
K
I
S
P
N
S
A
I
Y
S
P
A
V
F
P
W
E
I
P
L
L
A
Y
I
G
V
D
Y
F
D
D
S
L
A
K
L
Y
A
S
M
G
Y
K
F
T
K
N
R
A
V
K
V
D
S
F
S
F
E
E
L
Y
N
N
N
K
K
V
Y
E
E
I
L
E
E
V
R
I
A
I
K
N
G
F
L
R
N
V
V
E
E
T
A
V
S
H
P
Y
L
W
A
N
Y
R
R
Y
E
P
D
L
R
N
I
P
L
S
K
E
N
K
I
I
V
T
T
N
I
N
I
P
E
V
K
K
Y
L
E
R
L
D
N
Y
E
P
Y
S
N
I
I
V
L
L
P
C
S
S
K
K
P
Y
S
I
S
Q
S
H
Q
K
F
I
K
A
I
K
S
A
K
V
V
V
E
E
V
I
L
T
S
P
Y
G
L
V
P
R
A
L
E
R
L
V
N
Y
D
I
P
V
T
G
E
W
S
F
E
E
I
E
L
I
N
N
C
L
K
N
F
L
K
K
V
K
E
K
F
D
D
Y
I
V
I
A
H
L
P
E
H
Y
L
E
I
L
E
L
D
D
I
V
I
T
S
K
G
N
P
T
S
E
E
A
L
K
N
L
T
D
T
L
K
K
Y
K
E
L
T
K
S
K
D
I
N
K
K
G
Q
R
I
H
N
I
Q
Q
L
A
E
F
Q
F
G
I
N
F
I
P
N
E
I
F
I
N
H
K
G
Q
I
F
T
K
I
N
N
K
N
Q
Q
I
A
S
I
N
P
K
N
G
L
L
I
L
T
L
S
G
G
E
L
L
W
N
S
G
G
K
D
I
N
Y
I
E
V
N
Y
E
I
K
K
G
S
L
F
P
P
G
F
V
D
C
N
E
N
I
S
Y
N
D
E
V
V
L
I
K
D
D
T
F
L
G
I
G
R
A
L
M
S
G
F
E
M
K
K
A
K
H
G
A
L
V
N
I
R
N
V
K
S
50 100 150 200 250 300 350 400 450 500 550 Sequence G H T S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
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