Full name: tRNA (cytosine(38)-C(5))-methyltransferase
Synonym: GSU0227
GI: 39995337
Orf:
COG:
UniProt: Q74GL9
Structures: | |
Complex:
Enzyme type: methyltransferase
Position of modification - modification: t:38 - m5C

Comments:

In contrast to Dnmt2 methyltransferases from eukaryotes which methylate C38 of tRNAAsp, this enzyme methylates C38 in tRNAGlu. This swapped tRNA specificity is dependent on the differences in the sequence of variable loop in the substrate tRNAs.

Protein sequence:

MRAVELFCGIGGFAAAVEGTGVRVVAAMDQDEAALATYRLNFPGHGARKVDLERVSAWELTAGGVDLWWL SPPCQPYCERGVRRDLADPRARSLVHILNLAARMSDEALPRHLALENVAGFVGSEAHGRLTEVLSSRGYR LQERLLCPTELGIPSRRPRYYLAASRESLAPAEVLSPLPRQPLAEYLDLLPANGQPAELLLSPAIVERFG AGFRILDPADPDAYTTCFTSGYGRSLTASGAYLRCSDGVRRFSPEEIARLLHFPPSFRFPEEVPLRKRWQ LVGNSLSVAAVREVLRALPLPAEEG

Enzymatic activities:

Reaction Substrate Type Position
C:m5C tRNA (t) Glu/unknown/prokaryotic cytosol 38

Publications:

Title Authors Journal Details PubMed Id DOI
The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu. Shanmugam R, Aklujkar M, Schafer M, Reinhardt R, Nickel O, Reuter G, Lovley DR, Ehrenhofer-Murray A, Nellen W, Ankri S, Helm M, Jurkowski TP, Jeltsch A... Nucleic Acids Res [details] 24711368 -

Links:

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