Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA methyltransferase 10 homolog A
Synonym: RG9MTD2
GI: 22748659
UniProt: Q8TBZ6
Structures: | 4FMW |
Alpha Fold Predicted Structure: AF-Q8TBZ6-F1
Enzyme type: methyltransferase
Position of modification - modification: t:9 - m1G


PDB Structures:


4FMW

Structure Description:

Title:
Classification:
Technique:

Abstract of the PDB Structure's related Publication:



Download RCSB-PDB Structures:

Pdb Files   4FMW.pdb  
Pdbx/mmCIF Files   4FMW.cif  


Protein sequence:

MSSEMLPAFIETSNVDKKQGINEDQEESQKPRLGEGCEPISKRQMKKLIKQKQWEEQRELRKQKRKEKRKRKKLERQCQMEPNSDGHDRKRVRRDVVHSTLRLIIDCSFDHLMVLKDIKKLHKQIQRCYAENRRALHPVQFYLTSHGGQLKKNMDENDKGWVNWKDIHIKPEHYSELIKKEDLIYLTSDSPNILKELDESKAYVIGGLVDHNHHKGLTYKQASDYGINHAQLPLGNFVKMNSRKVLAVNHVFEIILEYLETRDWQEAFFTILPQRKGAVPTDKACESASHDNQSVRMEEGGSDSDSSEEEYSRNELDSPHEEKQDKENHTESTVNSLPH

Comments:

Ortholog of yeast Trm10, cytoplasmic. TRMT10A deficiency accounts for abnormalities in glucose homeostasis.




Reaction Substrate SubstrateType Position (Anti)Codon Modified (Anti)Codon Amino Acid Change Transcript Name Transcript Region Cellular Localization References
G:m1G tRNA (t) 9 23042678   

Alpha Fold Predicted Structure:






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Protein sequence:

M S S E M L P A F I E T S N V D K K Q G I N E D Q E E S Q K P R L G E G C E P I S K R Q M K K L I K Q K Q W E E Q R E L R K Q K R K E K R K R K K L E R Q C Q M E P N S D G H D R K R V R R D V V H S T L R L I I D C S F D H L M V L K D I K K L H K Q I Q R C Y A E N R R A L H P V Q F Y L T S H G G Q L K K N M D E N D K G W V N W K D I H I K P E H Y S E L I K K E D L I Y L T S D S P N I L K E L D E S K A Y V I G G L V D H N H H K G L T Y K Q A S D Y G I N H A Q L P L G N F V K M N S R K V L A V N H V F E I I L E Y L E T R D W Q E A F F T I L P Q R K G A V P T D K A C E S A S H D N Q S V R M E E G G S D S D S S E E E Y S R N E L D S P H E E K Q D K E N H T E S T V N S L P H

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q8TBZ6-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q8TBZ6-F1.cif  
DSSP Secondary Structures   Q8TBZ6.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. Vilardo E, Nachbagauer C, Buzet A, Taschner A, Holzmann J, Rossmanith W... Nucleic Acids Res [details] 23042678 -
TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly. Gillis D, Krishnamohan A, Yaacov B, Shaag A, Jackman JE, Elpeleg O... J Med Genet [details] 25053765 -

Links:

_PubMed -_