Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA methyltransferase 10 homolog B
Synonym: RG9MTD3
GI: 117606330
UniProt: Q6PF06
Alpha Fold Predicted Structure: AF-Q6PF06-F1
Enzyme type: methyltransferase
Position of modification - modification: t:9 - m1G



Protein sequence:

MDWKLEGSTQKVESPVLQGQEGILEETGEDGLPEGFQLLQIDAEGECQEGEILATGSTAWCSKNVQRKQRHWEKIVAAKKSKRKQEKERRKANRAENPGICPQHSKRFLRALTKDKLLEAKHSGPRLCIDLSMTHYMSKKELSRLAGQIRRLYGSNKKADRPFWICLTGFTTDSPLYEECVRMNDGFSSYLLDITEEDCFSLFPLETLVYLTPDSEHALEDVDLNKVYILGGLVDESIQKKVTFQKAREYSVKTARLPIQEYMVRNQNGKNYHSEILAINQVFDILSTYLETHNWPEALKKGVSSGKGYILRNSVE

Comments:

Ortholog of yeast Trm10, cytoplasmic.




Reaction Substrate SubstrateType Position (Anti)Codon Modified (Anti)Codon Amino Acid Change Transcript Name Transcript Region Cellular Localization References
G:m1G tRNA (t) 9 23042678   

Alpha Fold Predicted Structure:






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Protein sequence:

M D W K L E G S T Q K V E S P V L Q G Q E G I L E E T G E D G L P E G F Q L L Q I D A E G E C Q E G E I L A T G S T A W C S K N V Q R K Q R H W E K I V A A K K S K R K Q E K E R R K A N R A E N P G I C P Q H S K R F L R A L T K D K L L E A K H S G P R L C I D L S M T H Y M S K K E L S R L A G Q I R R L Y G S N K K A D R P F W I C L T G F T T D S P L Y E E C V R M N D G F S S Y L L D I T E E D C F S L F P L E T L V Y L T P D S E H A L E D V D L N K V Y I L G G L V D E S I Q K K V T F Q K A R E Y S V K T A R L P I Q E Y M V R N Q N G K N Y H S E I L A I N Q V F D I L S T Y L E T H N W P E A L K K G V S S G K G Y I L R N S V E

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q6PF06-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q6PF06-F1.cif  
DSSP Secondary Structures   Q6PF06.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. Vilardo E, Nachbagauer C, Buzet A, Taschner A, Holzmann J, Rossmanith W... Nucleic Acids Res [details] 23042678 -