Modomics - A Database of RNA Modifications

ID Card:

Full name: rRNA methyltransferase 1, mitochondrial
GI: 40068479
COG: COG0566
UniProt: Q6IN84
Alpha Fold Predicted Structure: AF-Q6IN84-F1
Enzyme type: methyltransferase
Position of modification - modification: l:1145(2251) - Gm



Protein sequence:

MALLSTVRGATWGRLVTRHFSHAARHGERPGGEELSRLLLDDLVPTSRLELLFGMTPCLLALQAARRSVARLLLQAGKAGLQGKRAELLRMAEARDIPVLRPRRQKLDTMCRYQVHQGVCMEVSPLRPRPWREAGEASPGDDPQQLWLVLDGIQDPRNFGAVLRSAHFLGVDKVITSRRNSCPLTPVVSKSSAGAMEVMDVFSTDDLTGFLQTKAQQGWLVAGTVGCPSTEDPQSSEIPIMSCLEFLWERPTLLVLGNEGSGLSQEVQASCQLLLTILPRRQLPPGLESLNVSVAAGILLHSICSQRKGFPTEGERRQLLQDPQEPSARSEGLSMAQHPGLSSGPEKERQNEG

Comments:

Mitochondrial.




Reaction Substrate SubstrateType Position (Anti)Codon Modified (Anti)Codon Amino Acid Change Transcript Name Transcript Region Cellular Localization References
G:Gm rRNA (r) LSU/16S/mitochondrion 1145 25074936   

Alpha Fold Predicted Structure:






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Protein sequence:

M A L L S T V R G A T W G R L V T R H F S H A A R H G E R P G G E E L S R L L L D D L V P T S R L E L L F G M T P C L L A L Q A A R R S V A R L L L Q A G K A G L Q G K R A E L L R M A E A R D I P V L R P R R Q K L D T M C R Y Q V H Q G V C M E V S P L R P R P W R E A G E A S P G D D P Q Q L W L V L D G I Q D P R N F G A V L R S A H F L G V D K V I T S R R N S C P L T P V V S K S S A G A M E V M D V F S T D D L T G F L Q T K A Q Q G W L V A G T V G C P S T E D P Q S S E I P I M S C L E F L W E R P T L L V L G N E G S G L S Q E V Q A S C Q L L L T I L P R R Q L P P G L E S L N V S V A A G I L L H S I C S Q R K G F P T E G E R R Q L L Q D P Q E P S A R S E G L S M A Q H P G L S S G P E K E R Q N E G

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q6IN84-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q6IN84-F1.cif  
DSSP Secondary Structures   Q6IN84.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
Assignment of 2'-O-methyltransferases to Modification Sites on the Mammalian Mitochondrial Large Subunit 16S rRNA. Lee KW, Bogenhagen DF... J Biol Chem [details] 25074936 -