TrmO from Escherichia coli - protein summary.
Position of modification - modification:
t:37 - m6t6A
TrmO has a unique single-sheeted beta-barrel structure and does not belong to any known classes of methyltransferases (as for August 2014). It employs S-adenosyl-L-methionine as a methyl donor and hence represents a novel category of AdoMet-dependent methyltransferase (Class VIII). In the tRNA substrate C31-G39 and G34 are major determinants of m6t6A formation.
The methyl group of the N6-methyl-N6-threonylcarbamoyladenosine in tRNA of Escherichia coli modestly improves the efficiency of the tRNA.
Qian Q, Curran JF, Bjork GR
Discovery of the beta-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs.
Kimura S, Miyauchi K, Ikeuchi Y, Thiaville PC, de Crecy-Lagard V, Suzuki T...
Nucleic Acids Res
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