Modomics - A Database of RNA Modifications

ID Card:

Full name: Methyltransferase-like protein 2A
Synonym: METTL2A
GI: 165932357
UniProt: Q96IZ6
Alpha Fold Predicted Structure: AF-Q96IZ6-F1
Enzyme type: methyltransferase



Protein sequence:

MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVPECRNNEDGPGLIMEEQHKCSSKSLEHKTQTLPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS

Comments:





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M A G S Y P E G A P A V L A D K R Q Q F G S R F L R D P A R V F H H N A W D N V E W S E E Q A A A A E R K V Q E N S I Q R V C Q E K Q V D Y E I N A H K Y W N D F Y K I H E N G F F K D R H W L F T E F P E L A P S Q N Q N H L K D W F L E N K S E V P E C R N N E D G P G L I M E E Q H K C S S K S L E H K T Q T L P V E E N V T Q K I S D L E I C A D E F P G S S A T Y R I L E V G C G V G N T V F P I L Q T N N D P G L F V Y C C D F S S T A I E L V Q T N S E Y D P S R C F A F V H D L C D E E K S Y P V P K G S L D I I I L I F V L S A I V P D K M Q K A I N R L S R L L K P G G M M L L R D Y G R Y D M A Q L R F K K G Q C L S G N F Y V R G D G T R V Y F F T Q E E L D T L F T T A G L E K V Q N L V D R R L Q V N R G K Q L T M Y R V W I Q C K Y C K P L L S S T S

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q96IZ6-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q96IZ6-F1.cif  
DSSP Secondary Structures   Q96IZ6.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans. Xu L, Liu X, Sheng N, Oo KS, Liang J, Chionh YH, Xu J, Ye F, Gao YG, Dedon PC, Fu XY J Biol Chem [details] 28655767 10.1074/jbc.M117.798298