Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA pseudouridine(38/39) synthase
GI: 199559784
Orf: FKSG32
UniProt: Q9BZE2
Alpha Fold Predicted Structure: AF-Q9BZE2-F1
Enzyme type: pseudouridine synthase



Protein sequence:

MAYNDTDRNQTEKLLKRVRELEQEVQRLKKEQAKNKEDSNIRENSAGAGKTKRAFDFSAHGRRHVALRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTRLVESRQTSNYHRCGRTDKGVSAFGQVISLDLRSQFPRGRDSEDFNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPVEPSFSARFSCLERTYRYFFPRADLDIVTMDYAAQKYVGTHDFRNLCKMDVANGVINFQRTILSAQVQLVGQSPGEGRWQEPFQLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKNPQKPQYSMAVEFPLVLYDCKFENVKWIYDQEAQEFNITHLQQLWANHAVKTHMLYSMLQGLDTVPVPCGIGPKMDGMTEWGNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKCQGLESRIQHFVRRGRIEHPHLFHEEETKAKRDCNDTLEEENTNLETPTKRVCVDTEIKSII

Comments:





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M A Y N D T D R N Q T E K L L K R V R E L E Q E V Q R L K K E Q A K N K E D S N I R E N S A G A G K T K R A F D F S A H G R R H V A L R I A Y M G W G Y Q G F A S Q E N T N N T I E E K L F E A L T K T R L V E S R Q T S N Y H R C G R T D K G V S A F G Q V I S L D L R S Q F P R G R D S E D F N V K E E A N A A A E E I R Y T H I L N R V L P P D I R I L A W A P V E P S F S A R F S C L E R T Y R Y F F P R A D L D I V T M D Y A A Q K Y V G T H D F R N L C K M D V A N G V I N F Q R T I L S A Q V Q L V G Q S P G E G R W Q E P F Q L C Q F E V T G Q A F L Y H Q V R C M M A I L F L I G Q G M E K P E I I D E L L N I E K N P Q K P Q Y S M A V E F P L V L Y D C K F E N V K W I Y D Q E A Q E F N I T H L Q Q L W A N H A V K T H M L Y S M L Q G L D T V P V P C G I G P K M D G M T E W G N V K P S V I K Q T S A F V E G V K M R T Y K P L M D R P K C Q G L E S R I Q H F V R R G R I E H P H L F H E E E T K A K R D C N D T L E E E N T N L E T P T K R V C V D T E I K S I I

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9BZE2-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9BZE2-F1.cif  
DSSP Secondary Structures   Q9BZE2.dssp  





Diseases connected to this enzyme:

Description Reaction Disease Name
A significant reduction in post-transcriptional pseudouridine modification of tRNA in patient cells has occurred. U:Y
Intellectual disability

Publications:

Title Authors Journal Details PubMed Id DOI
A homozygous truncating mutation in PUS3 expands the role of tRNA modification in normal cognition. Shaheen R, Han L, Faqeih E, Ewida N, Alobeid E, Phizicky EM, Alkuraya FS Hum Genet. [details] 27055666 10.1007/s00439-016-1665-7