Modomics - A Database of RNA Modifications

ID Card:

Full name: DR_0049
UniProt: Q9RYA1
Alpha Fold Predicted Structure: AF-Q9RYA1-F1
Enzyme type: methyltransferase



Protein sequence:

MSAPASSAPRLRLRVSKAAELHIRDGHPWVYESSVREQNREGEPGELAVVYDRRDRFLAIGLYDPFSPLRLRVLHTGMPTQLDDAWWAARLDAALARRAALFGPLTAFGDTDGYRVLNGESDGFPGLVVDRYAGVLVMKLYTAAWFPHLRRMLELFAARAPDFAVVLRLSRNIAERAADLGLHDGQVIYGELAGDSVVFRESGLRFEAEVRQGQKTGFFLDQRENRRRVEGLSEGRRVLNAFSFSGGFSLYAARGGASEVTSLDISAHALRSAERNFALNPELSAVHKTVQADVFEWLPAGKGSGADYDLVILDPPSLARREAEREGAIRAYGKLAEGGLTRLAPGGILVSASCSAHVSAEEFEEAVMSAVRRSGRRWRKLLSSRHAPDHHASFAEAEYLKAVFLQMD

Comments:

DR_0049 encodes the methyltransferase producing m5C2499 in D. radiodurans 23S rRNA. Growth experiments disclosed that inactivation of DR_0049 is associated with a severe growth defect.





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M S A P A S S A P R L R L R V S K A A E L H I R D G H P W V Y E S S V R E Q N R E G E P G E L A V V Y D R R D R F L A I G L Y D P F S P L R L R V L H T G M P T Q L D D A W W A A R L D A A L A R R A A L F G P L T A F G D T D G Y R V L N G E S D G F P G L V V D R Y A G V L V M K L Y T A A W F P H L R R M L E L F A A R A P D F A V V L R L S R N I A E R A A D L G L H D G Q V I Y G E L A G D S V V F R E S G L R F E A E V R Q G Q K T G F F L D Q R E N R R R V E G L S E G R R V L N A F S F S G G F S L Y A A R G G A S E V T S L D I S A H A L R S A E R N F A L N P E L S A V H K T V Q A D V F E W L P A G K G S G A D Y D L V I L D P P S L A R R E A E R E G A I R A Y G K L A E G G L T R L A P G G I L V S A S C S A H V S A E E F E E A V M S A V R R S G R R W R K L L S S R H A P D H H A S F A E A E Y L K A V F L Q M D

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9RYA1-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9RYA1-F1.cif  
DSSP Secondary Structures   Q9RYA1.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
Identification of the methyltransferase targeting C2499 in Deinococcus radiodurans 23S ribosomal RNA. Mundus J, Flyvbjerg KF, Kirpekar F Extremophiles [details] 26590840 10.1007/s00792-015-0800-z