ID Card:
Full name:
DR_0049
UniProt:
Q9RYA1
Alpha Fold Predicted Structure:
AF-Q9RYA1-F1
Enzyme type:
methyltransferase
Protein sequence:
MSAPASSAPRLRLRVSKAAELHIRDGHPWVYESSVREQNREGEPGELAVVYDRRDRFLAIGLYDPFSPLRLRVLHTGMPTQLDDAWWAARLDAALARRAALFGPLTAFGDTDGYRVLNGESDGFPGLVVDRYAGVLVMKLYTAAWFPHLRRMLELFAARAPDFAVVLRLSRNIAERAADLGLHDGQVIYGELAGDSVVFRESGLRFEAEVRQGQKTGFFLDQRENRRRVEGLSEGRRVLNAFSFSGGFSLYAARGGASEVTSLDISAHALRSAERNFALNPELSAVHKTVQADVFEWLPAGKGSGADYDLVILDPPSLARREAEREGAIRAYGKLAEGGLTRLAPGGILVSASCSAHVSAEEFEEAVMSAVRRSGRRWRKLLSSRHAPDHHASFAEAEYLKAVFLQMD
Comments:
DR_0049 encodes the methyltransferase producing m5C2499 in D. radiodurans 23S rRNA. Growth experiments disclosed that inactivation of DR_0049 is associated with a severe growth defect.
Alpha Fold Predicted Structure:
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Protein sequence:
M
S
A
P
A
S
S
A
P
R
L
R
L
R
V
S
K
A
A
E
L
H
I
R
D
G
H
P
W
V
Y
E
S
S
V
R
E
Q
N
R
E
G
E
P
G
E
L
A
V
V
Y
D
R
R
D
R
F
L
A
I
G
L
Y
D
P
F
S
P
L
R
L
R
V
L
H
T
G
M
P
T
Q
L
D
D
A
W
W
A
A
R
L
D
A
A
L
A
R
R
A
A
L
F
G
P
L
T
A
F
G
D
T
D
G
Y
R
V
L
N
G
E
S
D
G
F
P
G
L
V
V
D
R
Y
A
G
V
L
V
M
K
L
Y
T
A
A
W
F
P
H
L
R
R
M
L
E
L
F
A
A
R
A
P
D
F
A
V
V
L
R
L
S
R
N
I
A
E
R
A
A
D
L
G
L
H
D
G
Q
V
I
Y
G
E
L
A
G
D
S
V
V
F
R
E
S
G
L
R
F
E
A
E
V
R
Q
G
Q
K
T
G
F
F
L
D
Q
R
E
N
R
R
R
V
E
G
L
S
E
G
R
R
V
L
N
A
F
S
F
S
G
G
F
S
L
Y
A
A
R
G
G
A
S
E
V
T
S
L
D
I
S
A
H
A
L
R
S
A
E
R
N
F
A
L
N
P
E
L
S
A
V
H
K
T
V
Q
A
D
V
F
E
W
L
P
A
G
K
G
S
G
A
D
Y
D
L
V
I
L
D
P
P
S
L
A
R
R
E
A
E
R
E
G
A
I
R
A
Y
G
K
L
A
E
G
G
L
T
R
L
A
P
G
G
I
L
V
S
A
S
C
S
A
H
V
S
A
E
E
F
E
E
A
V
M
S
A
V
R
R
S
G
R
R
W
R
K
L
L
S
S
R
H
A
P
D
H
H
A
S
F
A
E
A
E
Y
L
K
A
V
F
L
Q
M
D
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
Identification of the methyltransferase targeting C2499 in Deinococcus radiodurans 23S ribosomal RNA.
Mundus J, Flyvbjerg KF, Kirpekar F
Extremophiles
[details]
26590840
10.1007/s00792-015-0800-z